Heartbeat: Heart disease and COVID-19.

During the COVID-19 pandemic it has become evident that the interaction between COVID-19 infection and cardiovascular disease goes both ways: patients with underlying cardiovascular disease (CVD) are at higher risk of adverse outcomes if infected; conversely, regardless of the presence of absence of underlying cardiovascular disease, acute myocardial injury is common in patients with COVID-19 infection. In this issue of Heart Wei and colleagues1 report that in a prospective study of 101 cases of COVID-19 in Sichuan, China, acute myocardial injury was present in 15.8% of patients, with an elevation in high-sensitivity troponin T (hs-TnT) more than five times normal in many patients. Clinical factors associated with an elevated hs-TnT were older age and pre-existing CVD. An elevated hs-TnT level was associated with a higher likelihood of mortality, admission to the intensive care unit, mechanical ventilation, and treatment with vasoactive agents. (table 1)

Table 1

In-hospital clinical outcomes in 101 cases of COVID-19 in Sichuan, China

	Total(n=101)	hs-TnT ≤14 pg/mL (n=85)	hs-TnT >14 pg/mL (n=16)	P value
Death, n (%)	3 (3.0)	0	3 (18.8)	<0.001
Severe case, n (%)	37 (36.6)	25 (29.4)	12 (75)	0.001
Admission to ICU, n (%)	31 (30.7)	21 (24.7)	10 (62.5)	0.003
Mechanical ventilation, n (%)	11 (10.9)	4 (4.7)	7 (43.5)	<0.001
Vasoactive agents, n (%)	5 (5.0)	0	5 (31.2)	<0.001
ICU duration, mean (SD)	3.26 (6.16)	2.86 (5.56)	5.38 (8.61)	0.135

ICU, intensive care unit.

In the accompanying editorial, Cheng and Leedy2 discuss the likely pathophysiology of myocardial injury in patient with COVID-19 infection including unmasking of underlying cardiovascular disease, coronary plaque rupture and cytokine release syndrome. They also emphasise the importance of identifying the underlying the mechanism of myocardial injury in each patient when possible suggesting that ‘A better understanding of the drivers of myocardial injury on a case-by-case basis would provide guidance in decision-making and steer clinicians towards the right direction of treatment to maximise the chance of myocardial recovery.’

In a study from Wuhan, China, Zhang and colleagues3 looked at the severity and outcomes of COVID-19 infection in patients with underlying CVD. Of the 541 patients with COVID-19, CVD was present in 26.6% and was associated with a higher mortality (22.2%) than in the overall study group (9.8%) and a higher proportion of critically ill patients (27.8% vs 8.8%). On multivariable logistic regression analysis, there was a lower likelihood of a full recovery and a higher risk of a critical disease course in those with underlying CVD (OR: 2.735 (95% CI 1.495 to 5.003).

Chaterjee and Cheng4 propose that the association between underlying CVD and risk of adverse outcomes with COVID-19 infection should inform our approach to care of our patients with CVD during the COVID-19 pandemic. (figure 1) Further, they put forth the idea that: ‘More broadly, given the potential effect modification of CVD on the effectiveness of clinical therapies for COVID-19, we would advocate stratifying analyses of investigational COVID-19 therapies by CVD status.’

Figure 1

Caring for the patient with CVD during the COVID-19 pandemic. CVD, cardiovascular disease; ICU, intensive care unit.

The association between CVD, myocardial injury and adverse outcomes in patients with COVID-19 infection was explored further in a systematic review and meta-analysis by Li and colleagues5 that included 10 studies with a total of over 3000 patients with COVID-19 infection. The OR for in-hospital mortality was almost five times higher for patients with underlying CVD, 3 to 4 times higher for those with hypertension, and 20 times higher for those with acute cardiac injury. (figure 2)

Figure 2

Forest plot of the relationship between pre-existing cardiovascular disease and in-hospital mortality risk in patients with COVID-19.

Newby and Rahimi6 comment that a ‘possible explanation for these associations is that the presence of cardiovascular disease is not only an indicator of older age but a marker of other non-cardiovascular comorbidities.’ ‘Nonetheless, there are a number of reasons to indicate that cardiovascular disease is mechanistically related to adverse outcome of COVID-19.’ ‘Overall, the systematic review by Li and colleagues5 has confirmed that, in patients with COVID-19, there are strong associations between mortality and cardiovascular disease or cardiac injury. These observed associations lend major support to the hypothesis of direct and indirect cardiovascular consequences as being a contributor to or a mediator of the increased mortality seen in patients with COVID-19.’

Also in this issue of Heart, three review articles address various aspects of COVID-19 infection and heart disease. Imazio and colleagues7 explore the potential mechanisms of myocardial injury in patients with COVID-19 infection. (figure 3)

Figure 3

Troponin elevation in the setting of COVID-19 can be related to non-ischaemic myocardial injury (blue circles) by different possible mechanisms (eg, severe hypoxia, sepsis, systemic inflammation, cytokine storm, pulmonary thrombosis and thromboembolism, stress cardiomyopathy, and myocarditis). Thicker lines underline the most common causes. SARS-CoV-2, severe acute respiratory syndrome coronavirus-2.

Rowland and Kunadian8 discuss the challenges we currently face in management of older patients with an acute coronary syndrome during the COVID-19 pandemic. The article by Khialani and MacCarthy9 outlines an approach to ensuring continued access to transcatheter aortic valve implantation during the COIVD-19 pandemic, balancing the risks of infection and use of limited supplies of personal protective equipment against the risk of adverse outcomes with in symptomatic adults with severe aortic stenosis who do not undergo prompt intervention.

Other articles recently published in print or online first in Heart related to COVID-19 infection include a review article on cardiovascular manifestations and treatment considerations,10 a short commentary on the effectiveness of masks based on previous experience with air pollution11 and a discussion of management of patients with adult congenital heart disease12 during the COVID-19 pandemic.