Literature DB >> 32718570

Gastric Biopsies in Gastroparesis: Insights into Gastric Neuromuscular Disorders to Aid Treatment.

Lakshmikanth L Chikkamenahalli1, Pankaj J Pasricha2, Gianrico Farrugia1, Madhusudan Grover3.   

Abstract

The cellular and molecular understanding of human gastroparesis has markedly improved due to studies on full-thickness gastric biopsies. A decrease in the number of interstitial cells of Cajal (ICC) and functional changes in ICC constitutes the hallmark cellular feature of gastroparesis. More recently, in animal models, macrophages have also been identified to play a central role in development of delayed gastric emptying. Activation of macrophages leads to loss of ICC. In human gastroparesis, loss of anti-inflammatory macrophages in gastric muscle has been shown. Deeper molecular characterization using transcriptomics and proteomics has identified macrophage-based immune dysregulation in human gastroparesis.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Diabetes; Enteric nervous system; Gastric emptying; Immune cells

Mesh：

Year:  2020        PMID： 32718570      PMCID： PMC7387746          DOI： 10.1016/j.gtc.2020.04.009

Source DB:  PubMed          Journal:  Gastroenterol Clin North Am        ISSN： 0889-8553            Impact factor:   3.806


  86 in total

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Authors:  S T Eisenman; S J Gibbons; P-J Verhulst; G Cipriani; D Saur; G Farrugia
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3.  Association of low numbers of CD206-positive cells with loss of ICC in the gastric body of patients with diabetic gastroparesis.

Authors:  C E Bernard; S J Gibbons; I S Mann; L Froschauer; H P Parkman; S Harbison; T L Abell; W J Snape; W L Hasler; R W McCallum; I Sarosiek; L A B Nguyen; K L Koch; J Tonascia; F A Hamilton; M L Kendrick; K R Shen; P J Pasricha; G Farrugia
Journal:  Neurogastroenterol Motil       Date:  2014-07-13       Impact factor: 3.598

4.  Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.

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10.  Transcriptomic signatures reveal immune dysregulation in human diabetic and idiopathic gastroparesis.

Authors:  Madhusudan Grover; Simon J Gibbons; Asha A Nair; Cheryl E Bernard; Adeel S Zubair; Seth T Eisenman; Laura A Wilson; Laura Miriel; Pankaj J Pasricha; Henry P Parkman; Irene Sarosiek; Richard W McCallum; Kenneth L Koch; Thomas L Abell; William J Snape; Braden Kuo; Robert J Shulman; Travis J McKenzie; Todd A Kellogg; Michael L Kendrick; James Tonascia; Frank A Hamilton; Gianrico Farrugia
Journal:  BMC Med Genomics       Date:  2018-08-07       Impact factor: 3.063
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