Zejun Zhang1, Huawei Zhu2, Yating Zheng1, Lanyue Zhang1, Xiaoling Wang2, Zhen Luo2, Jian Tang2, Li Lin3, Zhiyun Du4, Changzhi Dong5. 1. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China. 2. Infinitus (China) Company Ltd, Guangzhou, China. 3. Foshan Allen Conney Biological Technology Co. Ltd, Foshan, China. 4. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, China. Electronic address: zhiyundu@gdut.edu.cn. 5. Université Paris Diderot, Paris, France. Electronic address: dong@univ-paris-diderot.fr.
Abstract
BACKGROUND: The content of collagen and elastin occupies a large proportion of skin evaluation, and collagen peptide (CP) and elastin peptide (EP) are widely used drugs, which have anti-inflammatory effects. In addition, CP and EP can also be used as therapeutic agents for skin repair. However, previous studies have never thoroughly verified the effects of oral administration of CP and EP on skin repair. AIM: To study the effects and mechanism of oral administration of CP and EP on skin aging induced by combinatorial treatment with D-galactose and ultraviolet radiation. RESULTS: In animal experiments, the combined oral administration of CP and EP increased the contents of collagen and elastin in animal skin, accompanying with significantly upregulated expression of hyaluronic acid and hydroxyproline, as well as significantly reduced expression of MMP-3 and IL-1α. In addition, the combined therapy also significantly increased the expression of seven collagen and elastin synthesis-related factors including IGF-1, LOX, SMAD2, JNK, SP1, TβRII and TGF-β. CONCLUSION: Oral administration of CP and EP can repair skin aging induced by the combined treatment with D-galactose and ultraviolet radiation and the effects of CP and EP appeared synergistic.
BACKGROUND: The content of collagen and elastin occupies a large proportion of skin evaluation, and collagen peptide (CP) and elastin peptide (EP) are widely used drugs, which have anti-inflammatory effects. In addition, CP and EP can also be used as therapeutic agents for skin repair. However, previous studies have never thoroughly verified the effects of oral administration of CP and EP on skin repair. AIM: To study the effects and mechanism of oral administration of CP and EP on skin aging induced by combinatorial treatment with D-galactose and ultraviolet radiation. RESULTS: In animal experiments, the combined oral administration of CP and EP increased the contents of collagen and elastin in animal skin, accompanying with significantly upregulated expression of hyaluronic acid and hydroxyproline, as well as significantly reduced expression of MMP-3 and IL-1α. In addition, the combined therapy also significantly increased the expression of seven collagen and elastin synthesis-related factors including IGF-1, LOX, SMAD2, JNK, SP1, TβRII and TGF-β. CONCLUSION: Oral administration of CP and EP can repair skin aging induced by the combined treatment with D-galactose and ultraviolet radiation and the effects of CP and EP appeared synergistic.