Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The Concordance Between Imaging and Adrenal Vein Sampling Varies With Aldosterone-Driver Somatic Mutation.

Literature DB >> 32717082

The Concordance Between Imaging and Adrenal Vein Sampling Varies With Aldosterone-Driver Somatic Mutation.

Taweesak Wannachalee^1,2, Elaine Caoili³, Kazutaka Nanba⁴, Aya Nanba¹, William E Rainey⁴, James J Shields³, Adina F Turcu¹.

Abstract

BACKGROUND: Correct subtyping of primary aldosteronism (PA) is critical for guiding clinical management. Adrenal imaging is less accurate than adrenal vein sampling (AVS); nonetheless, AVS is invasive, technically challenging, and scarcely available.
OBJECTIVE: To identify predictors of concordance between cross-sectional imaging and lateralized AVS in patients with PA that could help circumvent AVS in a subset of patients.
METHODS: We retrospectively studied all patients with PA who underwent AVS in a tertiary referral center from 2009 to 2019. AVS was performed before and after cosyntropin stimulation. Patients with lateralized AVS in at least one condition were included. Aldosterone synthase-guided next-generation sequencing was performed on available adrenal tissue. Logistic regression was implemented to identify predictors of imaging-AVS lateralization concordance.
RESULTS: A total of 234 patients (62% men), age 20 to 79 years, 73% white, 23% black, and 2% Asian were included. AVS lateralization was found: 1) both pre- and post-cosyntropin (Uni/Uni) in 138 patients; 2) only at baseline (Uni/Bi) in 39 patients; 3) only after cosyntropin stimulation (Bi/Uni) in 29 patients. Catheterization partially failed in 28 patients. AVS-imaging agreement was higher in patients with KCNJ5 versus other aldosterone-driver somatic mutations (90.3% versus 64.6%; P < 0.001); in Asian and white versus black Americans (75%, 70%, and 36%, respectively); in younger patients; and those with left adrenal nodules and contralateral suppression. Conversely, AVS-imaging agreement was lowest in Uni/Bi patients (38% vs. 69% in Uni/Uni, and 62% in Bi/Uni; P = 0.007).
CONCLUSIONS: While AVS-imaging agreement is higher in young white and Asian patients, who have KCNJ5-mutated aldosterone producing adenomas, no predictor confers absolute imaging accuracy. © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities: Chemical

Keywords: adrenal; adrenal vein sampling; aldosterone; computed tomography; imaging; primary aldosteronism

Mesh：

Substances：

Year: 2020 PMID： 32717082 PMCID： PMC7437239 DOI： 10.1210/clinem/dgaa482

Source DB: PubMed Journal: J Clin Endocrinol Metab ISSN： 0021-972X Impact factor: 5.958

51 in total

1. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism.

Authors: Francesco Fallo; Franco Veglio; Chiara Bertello; Nicoletta Sonino; Paolo Della Mea; Mario Ermani; Franco Rabbia; Giovanni Federspil; Paolo Mulatero
Journal: J Clin Endocrinol Metab Date: 2005-11-15 Impact factor: 5.958

2. Adrenal nodularity and somatic mutations in primary aldosteronism: one node is the culprit?

Authors: T Dekkers; M ter Meer; J W M Lenders; A R M Hermus; L Schultze Kool; J F Langenhuijsen; K Nishimoto; T Ogishima; K Mukai; E A B Azizan; B Tops; J Deinum; B Küsters
Journal: J Clin Endocrinol Metab Date: 2014-04-23 Impact factor: 5.958

3. Lateralization index but not contralateral suppression at adrenal vein sampling predicts improvement in blood pressure after adrenalectomy for primary aldosteronism.

Authors: M Tagawa; M Ghosn; H Wachtel; D Fraker; R R Townsend; S Trerotola; D L Cohen
Journal: J Hum Hypertens Date: 2017-01-12 Impact factor: 3.012

4. Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

Authors: Kazutaka Nanba; Kei Omata; Celso E Gomez-Sanchez; Constantine A Stratakis; Andrew P Demidowich; Mari Suzuki; Lester D R Thompson; Debbie L Cohen; James M Luther; Lan Gellert; Anand Vaidya; Justine A Barletta; Tobias Else; Thomas J Giordano; Scott A Tomlins; William E Rainey
Journal: Hypertension Date: 2019-04 Impact factor: 10.190

5. Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations.

Authors: Takashi Okamura; Yasuyo Nakajima; Akiko Katano-Toki; Kazuhiko Horiguchi; Shunichi Matsumoto; Satoshi Yoshino; Eijiro Yamada; Takuya Tomaru; Sumiyasu Ishii; Tsugumichi Saito; Atsushi Ozawa; Nobuyuki Shibusawa; Tetsurou Satoh; Shuichi Okada; Rin Nagaoka; Daisuke Takada; Jun Horiguchi; Tetsunari Oyama; Masanobu Yamada
Journal: Endocr J Date: 2016-09-28 Impact factor: 2.349

6. Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism.

Authors: Hironobu Umakoshi; Tatsuki Ogasawara; Yoshiyu Takeda; Isao Kurihara; Hiroshi Itoh; Takuyuki Katabami; Takamasa Ichijo; Norio Wada; Yui Shibayama; Takanobu Yoshimoto; Yoshihiro Ogawa; Junji Kawashima; Masakatsu Sone; Nobuya Inagaki; Katsutoshi Takahashi; Minemori Watanabe; Yuichi Matsuda; Hiroki Kobayashi; Hirotaka Shibata; Kohei Kamemura; Michio Otsuki; Yuichi Fujii; Koichi Yamamto; Atsushi Ogo; Toshihiko Yanase; Shintaro Okamura; Shozo Miyauchi; Tomoko Suzuki; Mika Tsuiki; Mitsuhide Naruse
Journal: Clin Endocrinol (Oxf) Date: 2018-03-13 Impact factor: 3.478

Review 7. Prevalence of primary aldosteronism in patient's cohorts and in population-based studies--a review of the current literature.

Authors: A Hannemann; H Wallaschofski
Journal: Horm Metab Res Date: 2011-12-01 Impact factor: 2.936

8. Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.

Authors: Kei Omata; Fumitoshi Satoh; Ryo Morimoto; Sadayoshi Ito; Yuto Yamazaki; Yasuhiro Nakamura; Sharath K Anand; Zeng Guo; Michael Stowasser; Hironobu Sasano; Scott A Tomlins; William E Rainey
Journal: Hypertension Date: 2018-10 Impact factor: 10.190

The Concordance Between Imaging and Adrenal Vein Sampling Varies With Aldosterone-Driver Somatic Mutation.

1. Prevalence and characteristics of the metabolic syndrome in primary aldosteronism.

2. Adrenal nodularity and somatic mutations in primary aldosteronism: one node is the culprit?

3. Lateralization index but not contralateral suppression at adrenal vein sampling predicts improvement in blood pressure after adrenalectomy for primary aldosteronism.

4. Genetic Characteristics of Aldosterone-Producing Adenomas in Blacks.

5. Characteristics of Japanese aldosterone-producing adenomas with KCNJ5 mutations.

6. Accuracy of adrenal computed tomography in predicting the unilateral subtype in young patients with hypokalaemia and elevation of aldosterone in primary aldosteronism.

Review 7. Prevalence of primary aldosteronism in patient's cohorts and in population-based studies--a review of the current literature.

8. Cellular and Genetic Causes of Idiopathic Hyperaldosteronism.

9. Role of unilateral adrenalectomy in bilateral primary aldosteronism: a 22-year single center experience.

10. Adrenal vein sampling in primary aldosteronism: towards a standardised protocol.

1. The Role of Urinary Extracellular Vesicles Sodium Chloride Cotransporter in Subtyping Primary Aldosteronism.

2. Approach to the Patient with Primary Aldosteronism: Utility and Limitations of Adrenal Vein Sampling.

3. ACTH Stimulation Maximizes the Accuracy of Peripheral Steroid Profiling in Primary Aldosteronism Subtyping.

Review 4. Recent Development toward the Next Clinical Practice of Primary Aldosteronism: A Literature Review.