| Literature DB >> 32716885 |
Izaz Raouf1, Salman Khalid1, Asif Khan1, Jaehun Lee2, Heung Soo Kim3, Min-Ho Kim4.
Abstract
Recent progress in nanotechnology has advanced the development of magnetic nanoparticle (MNP) hyperthermia as a potential therapeutic platform for treating diseases. Due to the challenges in reliably predicting the spatiotemporal distribution of temperature in the living tissue during the therapy of MNP hyperthermia, critical for ensuring the safety as well as efficacy of the therapy, the development of effective and reliable numerical models is warranted. This article provides a comprehensive review on the various mathematical methods for determining specific loss power (SLP), a parameter used to quantify the heat generation capability of MNPs, as well as bio-heat models for predicting heat transfer phenomena and temperature distribution in living tissue upon the application of MNP hyperthermia. This article also discusses potential applications of the bio-heat models of MNP hyperthermia for therapeutic purposes, particularly for cancer treatment, along with their limitations that could be overcome.Entities:
Keywords: Bio-heat modeling; Cancer treatment; Heat transfer analysis; Induction heating; Magnetic fluid hyperthermia; Specific loss power
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Year: 2020 PMID： 32716885 PMCID： PMC7410490 DOI： 10.1016/j.jtherbio.2020.102644
Source DB: PubMed Journal: J Therm Biol ISSN： 0306-4565 Impact factor: 2.902