Hiroshi Tomoda1, James B McAlpine2. 1. Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan. tomodah@pharm.kitasato-u.ac.jp. 2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL, 60612-7231, USA.