Literature DB >> 32712310

Fsp3: A new parameter for drug-likeness.

Wenxiu Wei1, Srinivasulu Cherukupalli1, Lanlan Jing1, Xinyong Liu2, Peng Zhan3.   

Abstract

The drug-likeness of a compound is a key factor during the initial phases of drug discovery. It can be defined as the similarity between compounds and drugs. Here, we collate research related to the fraction of sp3 carbon atoms (Fsp3), including related high-throughput screening (HTS) cases, structural modifications based on Fsp3, and strategies to improve it. We also introduce new synthetic methods for spirocyclic scaffolds. It is likely that the reasonable rigidity of spirocyclic scaffolds will provide a new generation of drug candidates.
Copyright © 2020 Elsevier Ltd. All rights reserved.

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Year:  2020        PMID： 32712310     DOI： 10.1016/j.drudis.2020.07.017

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  18 in total

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