| Literature DB >> 32710473 |
Niki R Patel1, Mark A Huffman1, Xiao Wang1, Bangwei Ding1, Mark McLaughlin1, Justin A Newman1, Teresa Andreani1, Kevin M Maloney1, Heather C Johnson1, Aaron M Whittaker1.
Abstract
A 5-step enantioselective synthesis of the potent anti-HIV nucleoside islatravir is reported. The highly efficient route was enabled by a novel enantioselective alkynylation of an α,β-unsaturated ketone, a unique ozonolysis-dealkylation cascade in water, and an enzymatic aldol-glycosylation cascade.Entities:
Keywords: asymmetric alkynylation; biocatalysis; ozonolysis; synthesis
Year: 2020 PMID： 32710473 DOI： 10.1002/chem.202003091
Source DB: PubMed Journal: Chemistry ISSN： 0947-6539 Impact factor: 5.236