Bunchoo Pongtanakul1, Nongnuch Sirachainan2, Pacharapan Surapolchai3, Pimlak Charoenkwan4, Worawut Choeyprasert4, Patcharee Komwilaisak5, Su-On Chainansamit6, Nittaya Witsanuyothin7, Yujinda Lertrakul8, Piya Rujkijyanont9, Somjai Kanjanapongkul10, Darintr Sosothikul11, Kleebsabai Sanpakit1, Thirachit Chotsampancharoen12, Somporn Wangruangsathit13, Nintita Sripaiboonkij Thokanit14, Sommaphun Tabjareon1, Suradej Hongeng15. 1. Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand. 2. Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand. 3. Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, 12120, Thailand. 4. Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand. 5. Department of Pediatrics, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. 6. Department of Pediatrics, Khon Kaen Hospital, Khon Kaen, 40000, Thailand. 7. Department of Pediatrics, Nakhon Ratchasima Hospital, Nakhon Ratchasima, 30000, Thailand. 8. Department of Pediatrics, Sappasitthiprasong Hospital, Ubon Ratchathani, 34000, Thailand. 9. Department of Pediatrics, Phramongkutklao Hospital, Bangkok, 10400, Thailand. 10. Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, 10400, Thailand. 11. Department of Pediatrics, Faculty of Medicine, King Chulalongkorn Memorial Hospital, Chulalongkorn University, Bangkok, 10330, Thailand. 12. Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand. 13. Department of Pediatrics, Buddhachinaraj Phitsanulok Hospital, Phitsanulok, 65000, Thailand. 14. Ramathibodi Comprehensive Cancer Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand. 15. Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand. suradej.hon@mahidol.ac.th.
Abstract
BACKGROUND: Few epidemiological studies of pediatric central nervous system (CNS) tumors have been performed using data from Southeast Asian national registries. Therefore, we aimed to examine data on CNS tumors from the first national childhood CNS tumor registry in Thailand. METHODS: Newly diagnosed children with benign and malignant primary CNS tumors from 20 nationwide hospitals were included. Two eras in the Thai registry were studied to compare national protocol effectiveness, including 2003-2005 (before establishment of a pediatric CNS tumor protocol) and 2011-2012 (post-establishment). RESULTS: The first study period had 300 patients with an incidence of 7.5/1,000,000 person-years and the second had 168 patients with an incidence of 13.24/1,000,000 person-years. The three most common tumors were gliomas, medulloblastoma/primitive neuroectodermal tumor (PNET), and germ cell tumors. The most common tumor site was the cerebellum, followed by the brainstem and pineal region. Five- and 10-year overall survival (OS) rates were 46.62% (95% confidence interval [CI] 40.85-52.18) and 41.78% (95% CI 36.11-47.34), respectively, for the first period. The second period had a 5-year OS of 64.75% (95% CI 56.70-71.68). OS rates for gliomas, germ cell tumors, medulloblastoma/PNET, and ependymomas were better in the second period than in the first period. CONCLUSIONS: The incidence of primary childhood CNS tumors in our study is lower compared with other reports. Improvement of OS in the second study period might be because of establishment of the Thai Pediatric Oncology Group, and national protocols for childhood CNS tumors.
BACKGROUND: Few epidemiological studies of pediatric central nervous system (CNS) tumors have been performed using data from Southeast Asian national registries. Therefore, we aimed to examine data on CNS tumors from the first national childhood CNS tumor registry in Thailand. METHODS: Newly diagnosed children with benign and malignant primary CNS tumors from 20 nationwide hospitals were included. Two eras in the Thai registry were studied to compare national protocol effectiveness, including 2003-2005 (before establishment of a pediatric CNS tumor protocol) and 2011-2012 (post-establishment). RESULTS: The first study period had 300 patients with an incidence of 7.5/1,000,000 person-years and the second had 168 patients with an incidence of 13.24/1,000,000 person-years. The three most common tumors were gliomas, medulloblastoma/primitive neuroectodermal tumor (PNET), and germ cell tumors. The most common tumor site was the cerebellum, followed by the brainstem and pineal region. Five- and 10-year overall survival (OS) rates were 46.62% (95% confidence interval [CI] 40.85-52.18) and 41.78% (95% CI 36.11-47.34), respectively, for the first period. The second period had a 5-year OS of 64.75% (95% CI 56.70-71.68). OS rates for gliomas, germ cell tumors, medulloblastoma/PNET, and ependymomas were better in the second period than in the first period. CONCLUSIONS: The incidence of primary childhood CNS tumors in our study is lower compared with other reports. Improvement of OS in the second study period might be because of establishment of the Thai Pediatric Oncology Group, and national protocols for childhood CNS tumors.
Authors: Carol Kruchko; Haley Gittleman; Jennifer Ruhl; Jim Hofferkamp; Elizabeth M Ward; Quinn T Ostrom; Recinda L Sherman; Sandra F Jones; Jill S Barnholtz-Sloan; Reda J Wilson Journal: Neurooncol Pract Date: 2019-07-02
Authors: Dragana Stanić; Danica Grujičić; Tatjana Pekmezović; Jelena Bokun; Marija Popović-Vuković; Dragana Janić; Lejla Paripović; Vesna Ilić; Marija Pudrlja Slović; Rosanda Ilić; Savo Raičević; Milan Sarić; Ivana Mišković; Borko Nidžović; Marina Nikitović Journal: PLoS One Date: 2021-10-26 Impact factor: 3.240