Erick Gerday1,2, Jennifer B Brereton1, Timothy M Bahr2, Jennifer O Elmont1, Susan Fullmer3, Bruce A Middleton4, Diane M Ward5,6, Robin K Ohls1,2, Robert D Christensen7,8,9. 1. Intermountain Healthcare, Women and Newborns Clinical Program, Salt Lake City, UT, USA. 2. Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. 3. Department of Nutrition, Dietetics, and Food Science, Brigham Young University, Provo, UT, USA. 4. Intermountain Healthcare, Clinical Laboratories, Murray, UT, USA. 5. Center for Iron and Heme Disorders, University of Utah, Salt Lake City, UT, USA. 6. Department of Pathology, University of Utah Health, Salt Lake City, UT, USA. 7. Intermountain Healthcare, Women and Newborns Clinical Program, Salt Lake City, UT, USA. Robert.christensen@hsc.utah.edu. 8. Department of Pediatrics, Division of Neonatology, University of Utah Health, Salt Lake City, UT, USA. Robert.christensen@hsc.utah.edu. 9. Department of Pediatrics, Division of Hematology/Oncology, University of Utah, Salt Lake City, UT, USA. Robert.christensen@hsc.utah.edu.
Abstract
OBJECTIVE: Building on our previous study, showing a correlation between ferritin in serum and urine, we conducted a feasibility evaluation, measuring urinary ferritin as a potential noninvasive screening test for iron deficiency among NICU patients. STUDY DESIGN: This was a prospective analysis of paired serum/urine ferritin levels. We defined iron-limited erythropoiesis by a RET-He <5th percentile lower reference interval (<28 pg). RESULTS: We obtained 49 paired serum/urine samples from neonates judged as at-risk for iron deficiency. Urine ferritin ("corrected" for urine creatinine and specific gravity) correlated with serum ferritin (correlation coefficient of log10-transformed values 0.44). A corrected urine ferritin <12 ng/mL had a sensitivity of 82% (95% CI, 67-93%) and a specificity of 100% (CI, 66-100%) for detecting iron-limited erythropoiesis, with a positive predictive value of 100% (CI, 89-100%). CONCLUSIONS: Measuring urinary ferritin in NICU patients is feasible. Since low values identify iron-limitation, this could become a useful noninvasive screen.
OBJECTIVE: Building on our previous study, showing a correlation between ferritin in serum and urine, we conducted a feasibility evaluation, measuring urinary ferritin as a potential noninvasive screening test for iron deficiency among NICU patients. STUDY DESIGN: This was a prospective analysis of paired serum/urine ferritin levels. We defined iron-limited erythropoiesis by a RET-He <5th percentile lower reference interval (<28 pg). RESULTS: We obtained 49 paired serum/urine samples from neonates judged as at-risk for iron deficiency. Urine ferritin ("corrected" for urine creatinine and specific gravity) correlated with serum ferritin (correlation coefficient of log10-transformed values 0.44). A corrected urine ferritin <12 ng/mL had a sensitivity of 82% (95% CI, 67-93%) and a specificity of 100% (CI, 66-100%) for detecting iron-limited erythropoiesis, with a positive predictive value of 100% (CI, 89-100%). CONCLUSIONS: Measuring urinary ferritin in NICU patients is feasible. Since low values identify iron-limitation, this could become a useful noninvasive screen.
Authors: Timothy M Bahr; Nicholas R Carr; Thomas R Christensen; Jacob Wilkes; Elizabeth A O'Brien; Kendell R German; Robin K Ohls; Diane M Ward; Robert D Christensen Journal: Blood Cells Mol Dis Date: 2021-05-06 Impact factor: 2.372
Authors: Timothy M Bahr; Diane M Ward; Xuan Jia; Robin K Ohls; Kendell R German; Robert D Christensen Journal: Blood Cells Mol Dis Date: 2021-01-06 Impact factor: 2.372