C Mary Healy1, Marcia A Rench2, Laurie S Swaim3, Audra Timmins3, Anuja Vyas3, Haleh Sangi-Haghpeykar4, Nancy Ng2, Gowrisankar Rajam5, Fiona Havers5, Jarad Schiffer5, Carol J Baker6. 1. Departments of Pediatrics, Infectious Disease Section, Baylor College of Medicine, Houston, TX, United States. Electronic address: chealy@bcm.edu. 2. Departments of Pediatrics, Infectious Disease Section, Baylor College of Medicine, Houston, TX, United States. 3. Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States. 4. Departments of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States; Departments of Statistics, Baylor College of Medicine, Houston, TX, United States. 5. Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States. 6. Departments of Pediatrics, Infectious Disease Section, Baylor College of Medicine, Houston, TX, United States; Currently at: Department of Pediatrics, Division of Infectious Diseases, McGovern Medical School at the University of Texas Health Science Center, Houston, TX, United States.
Abstract
BACKGROUND: Kinetics of Tdap-induced maternally-derived antibodies in infants are poorly understood. Pre-Tdap era data suggest that maternal pertussis antibodies in infants have a half-life of approximately 5-6 weeks. METHODS: 34 mother-infant pairs had blood collected before maternal Tdap vaccination, 4 weeks later, at delivery (maternal and cord), and at infant ages 3 and 6 weeks from June 2014-March 2015. Immunoglobulin G (IgG) to pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbrial proteins (FIM) and pertactin (PRN) was quantified by multiplex luminex assay (IU/ml). Geometric mean concentrations (GMCs) with 95% confidence intervals (C.I.) and half-life of pertussis antibodies were calculated. RESULTS: Tdap was administered to 34 women (mean age 31.1 years) at mean gestation 30.7 weeks (28-32.7). Mean neonatal gestation was 39.1 weeks (36-41.1) and mean birthweight was 3379 g (2580-4584). Four weeks post-Tdap vaccination, maternal pertussis-specific IgG GMCs increased ≥4-fold in 59%, 41%, 29% and 44% of women for PT, FHA, FIM and PRN, respectively, and then waned. The transplacental transport ratio of pertussis antibodies was 1.35 for PT, 1.41 for FHA, 1.31 for FIM and 1.36 for PRN. Between birth and age 6 weeks, infant serum GMC for PT-specific IgG decreased from 55.1 IU/mL (38.6-78.6) to 21.1 IU/ml (14.7-30.2), and the proportion of infants with PT levels ≥10 IU/ml fell from 97% to 67%. Half-life of pertussis-specific IgG in infants in days was 29.4 (95% CI 27.3-31.7) for PT, 29.8 (95% CI 27.7-32.2) for FHA, 31.2 (95% CI 28.9-33.7) for PRN, and 35.8 (95% CI 30.1-44.3) for FIM. CONCLUSION: The half-life of pertussis-specific antibodies in infants induced by maternal Tdap vaccination (29-36 days) is shorter than previously reported. Understanding how the durability of passively-acquired antibodies impacts infant susceptibility to pertussis and response to primary vaccination is critical to refine prevention strategies.
BACKGROUND: Kinetics of Tdap-induced maternally-derived antibodies in infants are poorly understood. Pre-Tdap era data suggest that maternal pertussis antibodies in infants have a half-life of approximately 5-6 weeks. METHODS: 34 mother-infant pairs had blood collected before maternal Tdap vaccination, 4 weeks later, at delivery (maternal and cord), and at infant ages 3 and 6 weeks from June 2014-March 2015. Immunoglobulin G (IgG) to pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbrial proteins (FIM) and pertactin (PRN) was quantified by multiplex luminex assay (IU/ml). Geometric mean concentrations (GMCs) with 95% confidence intervals (C.I.) and half-life of pertussis antibodies were calculated. RESULTS:Tdap was administered to 34 women (mean age 31.1 years) at mean gestation 30.7 weeks (28-32.7). Mean neonatal gestation was 39.1 weeks (36-41.1) and mean birthweight was 3379 g (2580-4584). Four weeks post-Tdap vaccination, maternal pertussis-specific IgG GMCs increased ≥4-fold in 59%, 41%, 29% and 44% of women for PT, FHA, FIM and PRN, respectively, and then waned. The transplacental transport ratio of pertussis antibodies was 1.35 for PT, 1.41 for FHA, 1.31 for FIM and 1.36 for PRN. Between birth and age 6 weeks, infant serum GMC for PT-specific IgG decreased from 55.1 IU/mL (38.6-78.6) to 21.1 IU/ml (14.7-30.2), and the proportion of infants with PT levels ≥10 IU/ml fell from 97% to 67%. Half-life of pertussis-specific IgG in infants in days was 29.4 (95% CI 27.3-31.7) for PT, 29.8 (95% CI 27.7-32.2) for FHA, 31.2 (95% CI 28.9-33.7) for PRN, and 35.8 (95% CI 30.1-44.3) for FIM. CONCLUSION: The half-life of pertussis-specific antibodies in infants induced by maternal Tdap vaccination (29-36 days) is shorter than previously reported. Understanding how the durability of passively-acquired antibodies impacts infant susceptibility to pertussis and response to primary vaccination is critical to refine prevention strategies.
Authors: Mary Prahl; Yarden Golan; Arianna G Cassidy; Yusuke Matsui; Lin Li; Bonny Alvarenga; Hao Chen; Unurzul Jigmeddagva; Christine Y Lin; Veronica J Gonzalez; Megan A Chidboy; Lakshmi Warrier; Sirirak Buarpung; Amy P Murtha; Valerie J Flaherman; Warner C Greene; Alan H B Wu; Kara L Lynch; Jayant Rajan; Stephanie L Gaw Journal: Res Sq Date: 2021-12-15
Authors: Solohery L Razafimahatratra; Arthur Menezes; Amy Wesolowski; Lala Rafetrarivony; Simon Cauchemez; Richter Razafindratsimandresy; Aina Harimanana; Tania Crucitti; Jean Marc Collard; C J E Metcalf Journal: Epidemiol Infect Date: 2022-01-13 Impact factor: 2.451
Authors: Mary Prahl; Yarden Golan; Arianna G Cassidy; Yusuke Matsui; Lin Li; Bonny Alvarenga; Hao Chen; Unurzul Jigmeddagva; Christine Y Lin; Veronica J Gonzalez; Megan A Chidboy; Lakshmi Warrier; Sirirak Buarpung; Amy P Murtha; Valerie J Flaherman; Warner C Greene; Alan H B Wu; Kara L Lynch; Jayant Rajan; Stephanie L Gaw Journal: Nat Commun Date: 2022-07-30 Impact factor: 17.694