Literature DB >> 32709424

Flow cytometric identification of Tfh13 cells in mouse and human.

Jennifer S Chen1, Jessica D S Grassmann2, Uthaman Gowthaman1, Sam J Olyha1, Tregony Simoneau3, M Cecilia Berin4, Stephanie C Eisenbarth1, Adam Williams5.   

Abstract

Anaphylaxis is a life-threatening allergic reaction caused by cross-linking of high-affinity IgE antibodies on the surface of mast cells and basophils. Understanding the cellular mechanisms that lead to high-affinity IgE production is required to develop better therapeutics for preventing this severe reaction. A recently discovered population of T follicular helper Tfh13 cells regulates the production of high-affinity IgE in mouse models of allergy and can also be found in patients with allergies with IgE antibodies against food or aeroallergens. Here we describe optimized protocols for identifying Tfh13 cells in both mice and humans.
Copyright © 2020 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.

Entities:  

Keywords:  IL-13; IL-4; IL-5; IgE; T follicular helper cells; T(fh)13 cells; allergy; intracellular cytokine staining

Mesh：

Year:  2020        PMID： 32709424      PMCID： PMC7854882          DOI： 10.1016/j.jaci.2020.04.063

Source DB:  PubMed          Journal:  J Allergy Clin Immunol        ISSN： 0091-6749            Impact factor:   14.290


  16 in total

1.  Case fatality and population mortality associated with anaphylaxis in the United States.

Authors:  Larry Ma; Theodore M Danoff; Larry Borish
Journal:  J Allergy Clin Immunol       Date:  2013-12-14       Impact factor: 10.793

2.  Single-cell profiling of peanut-responsive T cells in patients with peanut allergy reveals heterogeneous effector TH2 subsets.

Authors:  David Chiang; Xintong Chen; Stacie M Jones; Robert A Wood; Scott H Sicherer; A Wesley Burks; Donald Y M Leung; Charuta Agashe; Alexander Grishin; Peter Dawson; Wendy F Davidson; Leah Newman; Robert Sebra; Miriam Merad; Hugh A Sampson; Bojan Losic; M Cecilia Berin
Journal:  J Allergy Clin Immunol       Date:  2018-01-31       Impact factor: 10.793

3.  T Follicular Helper Cell-Derived IL-4 Is Required for IgE Production during Intestinal Helminth Infection.

Authors:  Alexandre P Meli; Ghislaine Fontés; Cindy Leung Soo; Irah L King
Journal:  J Immunol       Date:  2017-05-22       Impact factor: 5.422

4.  An Inhibitory Role for the Transcription Factor Stat3 in Controlling IL-4 and Bcl6 Expression in Follicular Helper T Cells.

Authors:  Hao Wu; Lin-Lin Xu; Paulla Teuscher; Hong Liu; Mark H Kaplan; Alexander L Dent
Journal:  J Immunol       Date:  2015-07-17       Impact factor: 5.422

5.  Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion.

Authors:  Rimpei Morita; Nathalie Schmitt; Salah-Eddine Bentebibel; Rajaram Ranganathan; Laure Bourdery; Gerard Zurawski; Emile Foucat; Melissa Dullaers; SangKon Oh; Natalie Sabzghabaei; Elizabeth M Lavecchio; Marilynn Punaro; Virginia Pascual; Jacques Banchereau; Hideki Ueno
Journal:  Immunity       Date:  2011-01-06       Impact factor: 31.745

6.  Identification of a T follicular helper cell subset that drives anaphylactic IgE.

Authors:  Jennifer S Chen; Biyan Zhang; Adam Williams; Stephanie C Eisenbarth; Uthaman Gowthaman; William F Flynn; Yisi Lu; Wenzhi Song; Julie Joseph; Jake A Gertie; Lan Xu; Magalie A Collet; Jessica D S Grassmann; Tregony Simoneau; David Chiang; M Cecilia Berin; Joseph E Craft; Jason S Weinstein
Journal:  Science       Date:  2019-08-01       Impact factor: 47.728

7.  Follicular helper T cells are responsible for IgE responses to Der p 1 following house dust mite sensitization in mice.

Authors:  A Noble; J Zhao
Journal:  Clin Exp Allergy       Date:  2016-06-06       Impact factor: 5.018

8.  Airway exposure initiates peanut allergy by involving the IL-1 pathway and T follicular helper cells in mice.

Authors:  Joseph J Dolence; Takao Kobayashi; Koji Iijima; James Krempski; Li Y Drake; Alexander L Dent; Hirohito Kita
Journal:  J Allergy Clin Immunol       Date:  2017-12-14       Impact factor: 10.793

9.  A Ca(2+) concentration of 1.5 mM, as present in IMDM but not in RPMI, is critical for maximal response of Th cells to PMA/ionomycin.

Authors:  Jakob Zimmermann; Andreas Radbruch; Hyun-Dong Chang
Journal:  Eur J Immunol       Date:  2015-02-17       Impact factor: 5.532

10.  Cytokine-secreting follicular T cells shape the antibody repertoire.

Authors:  R Lee Reinhardt; Hong-Erh Liang; Richard M Locksley
Journal:  Nat Immunol       Date:  2009-03-01       Impact factor: 25.606
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  2 in total

1.  Oral anaphylaxis to peanut in a mouse model is associated with gut permeability but not with Tlr4 or Dock8 mutations.

Authors:  Jake A Gertie; Biyan Zhang; Elise G Liu; Laura R Hoyt; Xiangyun Yin; Lan Xu; Lauren L Long; Arielle Soldatenko; Uthaman Gowthaman; Adam Williams; Stephanie C Eisenbarth
Journal:  J Allergy Clin Immunol       Date:  2021-05-27       Impact factor: 14.290

Review 2.  Anaphylaxis: Focus on Transcription Factor Activity.

Authors:  Yanru Guo; Elizabeth Proaño-Pérez; Rosa Muñoz-Cano; Margarita Martin
Journal:  Int J Mol Sci       Date:  2021-05-06       Impact factor: 5.923
  2 in total

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