| Literature DB >> 32709244 |
Sha-Sha Cheng1, Guan-Jun Yang1, Wanhe Wang2, Chung-Hang Leung3, Dik-Lung Ma4.
Abstract
An amendment to this paper has been published and can be accessed via the original article.Entities:
Year: 2020 PMID: 32709244 PMCID: PMC7382088 DOI: 10.1186/s13045-020-00938-7
Source DB: PubMed Journal: J Hematol Oncol ISSN: 1756-8722 Impact factor: 17.388
Fig. 2The crystal structure of three different classes of PPIs [2]. A) Linear sequences comprise primary peptide epitopes (e.g. LM of DNA polymerase III bound to the binding pocket of the SC (PDB: 3D1F)); B) the secondary structure of epitopes binds as a single unit. e.g. an α-helix (NusB-NusE PPI (PDB: 3R2C)); and C) in tertiary structural epitopes, the binding interface is not continuous and both sides of PPI interface are needed (e.g. IL-2/IL-2Ra PPI (PDB 1Z92))