Literature DB >> 32707092

Therapeutic TVs for Crossing Barriers in the Brain.

Zhen Zhao1, Berislav V Zlokovic2.   

Abstract

Brain disorders are at the leading edge of global disease burden worldwide. Effective therapies are lagging behind because most drugs cannot reach their targets in the brain because of the blood-brain barrier (BBB). The new development of a BBB transport vehicle may bring us a step closer to solve this problem.
Copyright © 2020 Elsevier Inc. All rights reserved.

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Year:  2020        PMID： 32707092      PMCID： PMC7737504          DOI： 10.1016/j.cell.2020.06.041

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  12 in total

1.  Discovery of Novel Blood-Brain Barrier Targets to Enhance Brain Uptake of Therapeutic Antibodies.

Authors:  Y Joy Yu Zuchero; Xiaocheng Chen; Nga Bien-Ly; Daniela Bumbaca; Raymond K Tong; Xiaoying Gao; Shuo Zhang; Kwame Hoyte; Wilman Luk; Melanie A Huntley; Lilian Phu; Christine Tan; Dara Kallop; Robby M Weimer; Yanmei Lu; Donald S Kirkpatrick; James A Ernst; Ben Chih; Mark S Dennis; Ryan J Watts
Journal:  Neuron       Date:  2015-12-10       Impact factor: 17.173

Review 2.  Adeno-associated virus vector as a platform for gene therapy delivery.

Authors:  Dan Wang; Phillip W L Tai; Guangping Gao
Journal:  Nat Rev Drug Discov       Date:  2019-05       Impact factor: 84.694

3.  Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target.

Authors:  Y Joy Yu; Yin Zhang; Margaret Kenrick; Kwame Hoyte; Wilman Luk; Yanmei Lu; Jasvinder Atwal; J Michael Elliott; Saileta Prabhu; Ryan J Watts; Mark S Dennis
Journal:  Sci Transl Med       Date:  2011-05-25       Impact factor: 17.956

4.  Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle.

Authors:  Jens Niewoehner; Bernd Bohrmann; Ludovic Collin; Eduard Urich; Hadassah Sade; Peter Maier; Petra Rueger; Jan Olaf Stracke; Wilma Lau; Alain C Tissot; Hansruedi Loetscher; Anirvan Ghosh; Per-Ola Freskgård
Journal:  Neuron       Date:  2014-01-08       Impact factor: 17.173

5.  Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

Authors:  Y Joy Yu; Jasvinder K Atwal; Yin Zhang; Raymond K Tong; Kristin R Wildsmith; Christine Tan; Nga Bien-Ly; Maria Hersom; Janice A Maloney; William J Meilandt; Daniela Bumbaca; Kapil Gadkar; Kwame Hoyte; Wilman Luk; Yanmei Lu; James A Ernst; Kimberly Scearce-Levie; Jessica A Couch; Mark S Dennis; Ryan J Watts
Journal:  Sci Transl Med       Date:  2014-11-05       Impact factor: 17.956

Review 6.  Blood-Brain Barrier: From Physiology to Disease and Back.

Authors:  Melanie D Sweeney; Zhen Zhao; Axel Montagne; Amy R Nelson; Berislav V Zlokovic
Journal:  Physiol Rev       Date:  2019-01-01       Impact factor: 37.312

Review 7.  Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders.

Authors:  Melanie D Sweeney; Abhay P Sagare; Berislav V Zlokovic
Journal:  Nat Rev Neurol       Date:  2018-01-29       Impact factor: 42.937

8.  Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance.

Authors:  Zhen Zhao; Abhay P Sagare; Qingyi Ma; Matthew R Halliday; Pan Kong; Kassandra Kisler; Ethan A Winkler; Anita Ramanathan; Takahisa Kanekiyo; Guojun Bu; Nelly Chuqui Owens; Sanket V Rege; Gabriel Si; Ashim Ahuja; Donghui Zhu; Carol A Miller; Julie A Schneider; Manami Maeda; Takahiro Maeda; Tohru Sugawara; Justin K Ichida; Berislav V Zlokovic
Journal:  Nat Neurosci       Date:  2015-05-25       Impact factor: 24.884

9.  Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.

Authors:  Julie C Ullman; Annie Arguello; Jennifer A Getz; Akhil Bhalla; Cathal S Mahon; Junhua Wang; Tina Giese; Catherine Bedard; Do Jin Kim; Jessica R Blumenfeld; Nicholas Liang; Ritesh Ravi; Alicia A Nugent; Sonnet S Davis; Connie Ha; Joseph Duque; Hai L Tran; Robert C Wells; Steve Lianoglou; Vinay M Daryani; Wanda Kwan; Hilda Solanoy; Hoang Nguyen; Timothy Earr; Jason C Dugas; Michael D Tuck; Jennifer L Harvey; Michelle L Reyzer; Richard M Caprioli; Sejal Hall; Suresh Poda; Pascal E Sanchez; Mark S Dennis; Kannan Gunasekaran; Ankita Srivastava; Thomas Sandmann; Kirk R Henne; Robert G Thorne; Gilbert Di Paolo; Giuseppe Astarita; Dolores Diaz; Adam P Silverman; Ryan J Watts; Zachary K Sweeney; Mihalis S Kariolis; Anastasia G Henry
Journal:  Sci Transl Med       Date:  2020-05-27       Impact factor: 17.956

10.  Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.

Authors:  Mihalis S Kariolis; Robert C Wells; Jennifer A Getz; Wanda Kwan; Cathal S Mahon; Raymond Tong; Do Jin Kim; Ankita Srivastava; Catherine Bedard; Kirk R Henne; Tina Giese; Victoria A Assimon; Xiaocheng Chen; Yin Zhang; Hilda Solanoy; Katherine Jenkins; Pascal E Sanchez; Lesley Kane; Takashi Miyamoto; Kylie S Chew; Michelle E Pizzo; Nicholas Liang; Meredith E K Calvert; Sarah L DeVos; Sulochanadevi Baskaran; Sejal Hall; Zachary K Sweeney; Robert G Thorne; Ryan J Watts; Mark S Dennis; Adam P Silverman; Y Joy Yu Zuchero
Journal:  Sci Transl Med       Date:  2020-05-27       Impact factor: 17.956
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