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Literature DB >> 32705572

Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors.

Abstract

The use of allogeneic, pluripotent stem cell-derived immune cells for cancer immunotherapy has been the subject of recent research, including clinical trials. The use of pluripotent stem cells as the source for allogeneic immune cells facilitates stringent quality control of the final product, regarding efficacy, safety, and producibility. In this review, we have described the characteristics of natural killer (NK) cells from multiple cell sources, including pluripotent stem cells, the chimeric antigen receptor (CAR)-modification method and strategy for these NK cells, and the current and planned clinical trials of CAR-modified induced pluripotent stem cell-derived NK cells.

Entities: Chemical

Keywords: Chimeric antigen receptor; Immunotherapy; Induced pluripotent stem cell; Natural killer cell

Mesh：

Substances：

Year: 2020 PMID： 32705572 DOI： 10.1007/s12185-020-02951-5

Source DB: PubMed Journal: Int J Hematol ISSN： 0925-5710 Impact factor: 2.490

48 in total

1. Natural killer cell signaling pathways.

Authors: Eric Vivier; Jacques A Nunès; Frédéric Vély
Journal: Science Date: 2004-11-26 Impact factor: 47.728

2. Natural killer cell recognition of missing self.

Authors: Klas Kärre
Journal: Nat Immunol Date: 2008-05 Impact factor: 25.606

3. Continuous intravenous infusions of 5-fluoro-2'-deoxyuridine in the treatment of solid tumors.

Authors: R C DeConti; S R Kaplan; R J Papac; P Calabresi
Journal: Cancer Date: 1973-04 Impact factor: 6.860

4. CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.

Authors: Theodoros Giavridis; Sjoukje J C van der Stegen; Justin Eyquem; Mohamad Hamieh; Alessandra Piersigilli; Michel Sadelain
Journal: Nat Med Date: 2018-05-28 Impact factor: 53.440

5. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.

Authors: Jeffrey S Miller; Yvette Soignier; Angela Panoskaltsis-Mortari; Sarah A McNearney; Gong H Yun; Susan K Fautsch; David McKenna; Chap Le; Todd E Defor; Linda J Burns; Paul J Orchard; Bruce R Blazar; John E Wagner; Arne Slungaard; Daniel J Weisdorf; Ian J Okazaki; Philip B McGlave
Journal: Blood Date: 2005-01-04 Impact factor: 22.113

6. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia.

Authors: Jeffrey E Rubnitz; Hiroto Inaba; Raul C Ribeiro; Stanley Pounds; Barbara Rooney; Teresa Bell; Ching-Hon Pui; Wing Leung
Journal: J Clin Oncol Date: 2010-01-19 Impact factor: 44.544

Review 7. Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy.

Authors: Yuan Hu; Zhi-Gang Tian; Cai Zhang
Journal: Acta Pharmacol Sin Date: 2017-09-07 Impact factor: 6.150

8. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Authors: Z Eshhar; T Waks; G Gross; D G Schindler
Journal: Proc Natl Acad Sci U S A Date: 1993-01-15 Impact factor: 11.205

Induced pluripotent stem cell-derived natural killer cells gene-modified to express chimeric antigen receptor-targeting solid tumors.

1. Natural killer cell signaling pathways.

2. Natural killer cell recognition of missing self.

3. Continuous intravenous infusions of 5-fluoro-2'-deoxyuridine in the treatment of solid tumors.

4. CAR T cell-induced cytokine release syndrome is mediated by macrophages and abated by IL-1 blockade.

5. Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancer.

6. NKAML: a pilot study to determine the safety and feasibility of haploidentical natural killer cell transplantation in childhood acute myeloid leukemia.

Review 7. Chimeric antigen receptor (CAR)-transduced natural killer cells in tumor immunotherapy.

8. Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Review 9. NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma.

Review 10. Newtonian cell interactions shape natural killer cell education.

Review 1. Engineering NK Cells for CAR Therapy-Recent Advances in Gene Transfer Methodology.

Review 2. iPSC-Derived Natural Killer Cells for Cancer Immunotherapy.