Siraj Omar Wali1, Jamil Al-Mughales2,3, Faris Alhejaili4, Md Dilshad Manzar5, Fahad Alsallum6, Hashim Almojaddidi6, David Gozal7. 1. Sleep Medicine and Research Center, Sleep Medicine Research Group, Internal Medicine Department, Faculty of Medicine, College of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, POBOX 21589, Jeddah, 80215, Saudi Arabia. sowali@kau.edu.sa. 2. Diagnostic Immunology Division, Department of Clinical Laboratory Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. 3. Department of Medical Microbiology and Parasitology Immunology Division, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 4. Sleep Medicine and Research Center, Sleep Medicine Research Group, Internal Medicine Department, Faculty of Medicine, College of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, POBOX 21589, Jeddah, 80215, Saudi Arabia. 5. Department of Nursing, College of Applied Medical Sciences, Majmaah University, Majmaah, Saudi Arabia. 6. Medical Student, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. 7. Department of Child Health and the Child Health Research Institute, The University of Missouri School of Medicine, Columbia, MO, USA.
Abstract
PURPOSE: To evaluate the association of recently diagnosed obstructive sleep apnea (OSA) with TNF-α and IL-6 and to measure the effect of short-term continuous positive airway pressure (CPAP) therapy on these markers. METHODS: A prospective, open-label, controlled trial was conducted among patients referred for diagnostic polysomnography (PSG). After PSG, patients were divided into 3 groups: OSA intervention group (N = 21), OSA control untreated group (N = 19), and non-OSA control group (N = 24). IL-6 and TNF-α levels were measured at baseline and 1 month after intervention. Repeated measures (RM) ANOVA and ANCOVA were used to compare the three groups regarding changes in TNF-α and IL-6 levels by analyzing between-subject and within-subject effects as a function of time and adjusting for significant covariates. RESULTS: At baseline, IL-6 (p = 0.05) and TNF-α (p = 0.04) were significantly higher in the OSA patients than in the non-OSA controls. There was no effect of time either on the TNF-α (p = 0.069) or IL-6 (p = 0.717) after 1 month of CPAP. No interaction effect between group and time was found for either TNF-α (p = 0.240) or IL-6 (p = 0.552) after 1 month of CPAP. There was neither a group effect nor an interaction effect between group and time for either IL-6 or TNF α after adjusting for age, BMI, neck circumference, and AHI. CONCLUSION: This study showed increases in proinflammatory state as illustrated by plasma TNF-α and IL-6 levels among recently diagnosed OSA patients, but there were no changes in these inflammatory markers following 1-month CPAP therapy.
PURPOSE: To evaluate the association of recently diagnosed obstructive sleep apnea (OSA) with TNF-α and IL-6 and to measure the effect of short-term continuous positive airway pressure (CPAP) therapy on these markers. METHODS: A prospective, open-label, controlled trial was conducted among patients referred for diagnostic polysomnography (PSG). After PSG, patients were divided into 3 groups: OSA intervention group (N = 21), OSA control untreated group (N = 19), and non-OSA control group (N = 24). IL-6 and TNF-α levels were measured at baseline and 1 month after intervention. Repeated measures (RM) ANOVA and ANCOVA were used to compare the three groups regarding changes in TNF-α and IL-6 levels by analyzing between-subject and within-subject effects as a function of time and adjusting for significant covariates. RESULTS: At baseline, IL-6 (p = 0.05) and TNF-α (p = 0.04) were significantly higher in the OSA patients than in the non-OSA controls. There was no effect of time either on the TNF-α (p = 0.069) or IL-6 (p = 0.717) after 1 month of CPAP. No interaction effect between group and time was found for either TNF-α (p = 0.240) or IL-6 (p = 0.552) after 1 month of CPAP. There was neither a group effect nor an interaction effect between group and time for either IL-6 or TNF α after adjusting for age, BMI, neck circumference, and AHI. CONCLUSION: This study showed increases in proinflammatory state as illustrated by plasma TNF-α and IL-6 levels among recently diagnosed OSA patients, but there were no changes in these inflammatory markers following 1-month CPAP therapy.