Maud Alligier1, Anne-Laure Borel2, Véronique Savey3, Claire Rives-Lange4, Marie-Claude Brindisi5, Xavier Piguel6, David Nocca7, Maud Monsaingeon-Henry8, Emilie Montastier9, Sophia Beliard10, Cécile Bossu Estour11, Hélène Verkindt12, Muriel Coupaye13, Amal Lemoine14, Antoine Pierre15, Martine Laville16, Emmanuel Disse17, Cécile Bétry18. 1. F-CRIN/FORCE network, Human Nutrition Research Center, Lyon, France. 2. Department of Endocrinology, Diabetes and Nutrition, Grenoble Alpes University Hospital, "Hypoxia, Pathophysiology" Laboratory, INSERM U1042, Grenoble Alpes University, Grenoble, France. 3. CHU de Caen Normandie, Service d'Hépato-gastro-entérologie Nutrition et Chirurgie digestive Centre Spécialisé de l'Obésité du CHU de Caen Normandie, Caen, France. 4. AP-HP, Department of Nutrition, Hopˆital Européen Georges Pompidou, Paris, France. 5. Service d'Endocrinologie-Diabétologie-Maladies métaboliques, CSO Bourgogne, CHU Dijon Bourgogne, Dijon, France. 6. Service d'Endocrinologie, Diabétologie, Nutrition, CHU de Poitiers, Poitiers, France. 7. Equipe chirurgie bariatrique, CHU Montpellier, Institut de Genomique Fonctionnelle, UMR 5203, CNRS, U1191 INSERM, Université Montpellier, Montpellier, France. 8. Service d'Endocrinologie, Diabétologie et Nutrition, Centre Spécialisé de l'Obésité du CHU de Bordeaux, Hôpital Haut-Lévêque, Pessac, France. 9. Service d'Endocrinologie, Maladies métaboliques et Nutrition, Centre Intégré de l'Obésité de Toulouse, Centre Hospitalier Universitaire de Toulouse, Toulouse Cedex, France. 10. APHM, Nutrition, Metabolic diseases and Endocrinology department, Aix Marseille Univ, INSERM, INRAE, C2 VN, Marseille, France. 11. Centre Hospitalier Métropole de Savoie, France. 12. Department of General and Endocrine Surgery, CHU Lille, Lille, France. 13. Service des Explorations Fonctionnelles, Centre Intégré Nord Francilien de prise en charge de l'Obésité, Hôpital Louis Mourier (AP-HP), and Université de Paris, Inserm UMR 1149, Colombes, France. 14. CHR de Vienne, Vienne France. 15. CSO Champagne-Ardenne, CHU Reims Hôpital Robert-Debré, Reims Cedex, France. 16. Centre Intégré Obésité de Lyon, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, F-CRIN/FORCE Network, Pierre Bénite, France. 17. Centre Intégré Obésité de Lyon, Hospices Civils de Lyon, Université Claude Bernard Lyon 1, Pierre Bénite, France. 18. Service d'Endocrinologie, Diabétologie, Nutrition, CHU Grenoble Alpes, Grenoble, France. Electronic address: cbetry@chu-grenoble.fr.
Abstract
BACKGROUND: Neurologic complications after bariatric surgery are rare, but can have dramatic consequences. Little data are available on this topic. OBJECTIVES: The aim of the Neurologic complications after BARiatric surgery (NEUROBAR) study was to define, which factors (anthropometric, nutritional, surgical, etc.) were frequently associated with neurologic complications after bariatric surgery. SETTINGS: Data were collected by the French Centers of Obesity Care Management hosted in University Hospitals. METHODS: An online standardized questionnaire was designed and submitted to the 37 French Centers of Obesity Management. This questionnaire included items about patient characteristics, bariatric surgery, neurologic complications, nutritional status, and management. Patients were retrospectively included from January 2010 to November 2018. RESULTS: Thirteen centers included 38 patients (34 females and 4 males) with neurologic complications after bariatric surgery. The 2 main bariatric procedures were gastric bypass and sleeve gastrectomy. More than half of the patients with neurologic complications had a surgical complication after bariatric surgery (53%) and gastrointestinal symptoms, including vomiting (53%). Vitamin B deficiencies were frequent (74%) including at least 47% of cases with deficiency in Vitamin B1. CONCLUSION: Early identification of patients with surgical complications and gastrointestinal symptoms after bariatric surgery could help prevent neurologic complications related to nutritional deficiencies.
BACKGROUND: Neurologic complications after bariatric surgery are rare, but can have dramatic consequences. Little data are available on this topic. OBJECTIVES: The aim of the Neurologic complications after BARiatric surgery (NEUROBAR) study was to define, which factors (anthropometric, nutritional, surgical, etc.) were frequently associated with neurologic complications after bariatric surgery. SETTINGS: Data were collected by the French Centers of Obesity Care Management hosted in University Hospitals. METHODS: An online standardized questionnaire was designed and submitted to the 37 French Centers of Obesity Management. This questionnaire included items about patient characteristics, bariatric surgery, neurologic complications, nutritional status, and management. Patients were retrospectively included from January 2010 to November 2018. RESULTS: Thirteen centers included 38 patients (34 females and 4 males) with neurologic complications after bariatric surgery. The 2 main bariatric procedures were gastric bypass and sleeve gastrectomy. More than half of the patients with neurologic complications had a surgical complication after bariatric surgery (53%) and gastrointestinal symptoms, including vomiting (53%). Vitamin B deficiencies were frequent (74%) including at least 47% of cases with deficiency in Vitamin B1. CONCLUSION: Early identification of patients with surgical complications and gastrointestinal symptoms after bariatric surgery could help prevent neurologic complications related to nutritional deficiencies.