Peng Ni1, Mingyang Yu1, Rongguang Zhang2, Cheng Cheng1, Mengya He1, Haiyan Wang1, Shuaiyin Chen1, Guangcai Duan1. 1. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China. 2. Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, China; Department of Epidemiology, College of Public Health, Hainan Medical University, Haikou, China. Electronic address: zrg@zzu.edu.cn.
Abstract
PURPOSE: The purpose of the study is to quantitatively assess the association between C-reactive protein (CRP) and all-cause, cardiovascular disease (CVD), and cancer mortality; a dose-response meta-analysis was performed on data from cohort studies in general population. METHODS: The published relevant articles were searched for in PubMed, Web of Science, and Embase until September 21, 2019. The pooled relative risk (RR) was estimated by random effects of generalized least square regression models. The dose-response relationship was modeled using restricted cubic splines. RESULTS: Twenty-two articles were screened for the meta-analysis. Compared with the low CRP group, the pooled RR in the moderate CRP group was 1.30 (95% confidence interval (CI), 1.20-1.41) for all-cause mortality and 1.43 (95% CI, 1.22-1.68) for CVD mortality; the pooled RR in the high CRP group was 1.75 (95% CI, 1.59-1.92) for all-cause mortality, 2.02 (95% CI, 1.70-2.41) for CVD mortality, and 1.32 (95% CI, 1.21-1.45) for cancer mortality. CONCLUSIONS: This meta-analysis demonstrated the relationships between CRP and mortality were nonlinear for all-cause and CVD mortality and were linear for cancer and noncardiovascular mortality.
PURPOSE: The purpose of the study is to quantitatively assess the association between C-reactive protein (CRP) and all-cause, cardiovascular disease (CVD), and cancer mortality; a dose-response meta-analysis was performed on data from cohort studies in general population. METHODS: The published relevant articles were searched for in PubMed, Web of Science, and Embase until September 21, 2019. The pooled relative risk (RR) was estimated by random effects of generalized least square regression models. The dose-response relationship was modeled using restricted cubic splines. RESULTS: Twenty-two articles were screened for the meta-analysis. Compared with the low CRP group, the pooled RR in the moderate CRP group was 1.30 (95% confidence interval (CI), 1.20-1.41) for all-cause mortality and 1.43 (95% CI, 1.22-1.68) for CVDmortality; the pooled RR in the high CRP group was 1.75 (95% CI, 1.59-1.92) for all-cause mortality, 2.02 (95% CI, 1.70-2.41) for CVDmortality, and 1.32 (95% CI, 1.21-1.45) for cancer mortality. CONCLUSIONS: This meta-analysis demonstrated the relationships between CRP and mortality were nonlinear for all-cause and CVDmortality and were linear for cancer and noncardiovascular mortality.
Authors: Antonio Bernabe-Ortiz; Rodrigo M Carrillo-Larco; Robert H Gilman; Liam Smeeth; William Checkley; J Jaime Miranda Journal: Ann Epidemiol Date: 2021-12-16 Impact factor: 3.797
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