Objectives: To determine links between objectively and subjectively measured physical function and cognitive function among HIV-positive older adults, a growing yet understudied group with elevated risk for multimorbidity. Methods: At a biomedical research visit, 162 participants completed objective tests of gait speed (4-m walk), grip strength (dynamometer), and cognitive function (Montreal Cognitive Assessment, MoCA) and reported their well-being (Medical Outcomes Study-HIV survey). Results: Those with faster gait speed had better overall cognitive function than those with slower gait speed (b = 3.98, SE = 1.30, p = .003) in an adjusted regression model controlling for age, sex, race, height, preferred language, and assistive device use. Grip strength was not significantly associated with overall cognitive function. Self-rated cognitive function was weakly related to MoCA scores (r = .26) and gait speed (r = .14) but was strongly associated with emotional well-being (r = .53). Discussion: These observed, expected connections between physical and cognitive function could inform intervention strategies to mitigate age-related declines for older adults with HIV.
Objectives: To determine links between objectively and subjectively measured physical function and cognitive function among HIV-positive older adults, a growing yet understudied group with elevated risk for multimorbidity. Methods: At a biomedical research visit, 162 participants completed objective tests of gait speed (4-m walk), grip strength (dynamometer), and cognitive function (Montreal Cognitive Assessment, MoCA) and reported their well-being (Medical Outcomes Study-HIV survey). Results: Those with faster gait speed had better overall cognitive function than those with slower gait speed (b = 3.98, SE = 1.30, p = .003) in an adjusted regression model controlling for age, sex, race, height, preferred language, and assistive device use. Grip strength was not significantly associated with overall cognitive function. Self-rated cognitive function was weakly related to MoCA scores (r = .26) and gait speed (r = .14) but was strongly associated with emotional well-being (r = .53). Discussion: These observed, expected connections between physical and cognitive function could inform intervention strategies to mitigate age-related declines for older adults with HIV.
Authors: Ziad S Nasreddine; Natalie A Phillips; Valérie Bédirian; Simon Charbonneau; Victor Whitehead; Isabelle Collin; Jeffrey L Cummings; Howard Chertkow Journal: J Am Geriatr Soc Date: 2005-04 Impact factor: 5.562
Authors: Matteo Cesari; Stephen B Kritchevsky; Brenda W H J Penninx; Barbara J Nicklas; Eleanor M Simonsick; Anne B Newman; Frances A Tylavsky; Jennifer S Brach; Suzanne Satterfield; Douglas C Bauer; Marjolein Visser; Susan M Rubin; Tamara B Harris; Marco Pahor Journal: J Am Geriatr Soc Date: 2005-10 Impact factor: 5.562
Authors: Kristine M Erlandson; Kunling Wu; Susan L Koletar; Robert C Kalayjian; Ronald J Ellis; Babafemi Taiwo; Frank J Palella; Katherine Tassiopoulos Journal: J Infect Dis Date: 2017-03-15 Impact factor: 5.226
Authors: Kalpana J Kallianpur; Marissa Sakoda; Louie Mar A Gangcuangco; Lishomwa C Ndhlovu; Tracie Umaki; Dominic Chow; Suwarat Wongjittraporn; Cecilia M Shikuma Journal: Open Med J Date: 2016-08-29
Authors: Christian Eggers; Gabriele Arendt; Katrin Hahn; Ingo W Husstedt; Matthias Maschke; Eva Neuen-Jacob; Mark Obermann; Thorsten Rosenkranz; Eva Schielke; Elmar Straube Journal: J Neurol Date: 2017-05-31 Impact factor: 4.849