Literature DB >> 32697355

High glucose distinctively regulates Ca2+ influx in cytotoxic T lymphocytes upon target recognition and thapsigargin stimulation.

Huajiao Zou1,2, Wenjuan Yang2, Gertrud Schwär2, Renping Zhao2, Dalia Alansary3, Deling Yin1,4, Eva C Schwarz2, Barbara A Niemeyer3, Bin Qu2,5.   

Abstract

In CTLs: High glucose-culture enhances thapsigargin-induced SOCE but decreases target recognition-induced Ca2+ influx. High glucose-culture regulates expression of ORAIs and STIMs without affecting glucose uptake. More high glucose-cultured CTLs are prone to necrosis after execution of killing.
© 2020 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.

Entities:  

Keywords:  SOCE; calcium; cytotoxic T cells; glucose; metabolism

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Year:  2020        PMID： 32697355     DOI： 10.1002/eji.202048577

Source DB:  PubMed          Journal:  Eur J Immunol        ISSN： 0014-2980            Impact factor:   5.532


  2 in total

1.  Unspecific CTL Killing Is Enhanced by High Glucose via TNF-Related Apoptosis-Inducing Ligand.

Authors:  Wenjuan Yang; Andreas Denger; Caroline Diener; Frederic Küppers; Leticia Soriano-Baguet; Gertrud Schäfer; Archana K Yanamandra; Renping Zhao; Arne Knörck; Eva C Schwarz; Martin Hart; Frank Lammert; Leticia Prates Roma; Dirk Brenner; Grigorios Christidis; Volkhard Helms; Eckart Meese; Markus Hoth; Bin Qu
Journal:  Front Immunol       Date:  2022-02-21       Impact factor: 7.561

2.  High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.

Authors:  Jie Zhu; Wenjuan Yang; Xiangda Zhou; Dorina Zöphel; Leticia Soriano-Baguet; Denise Dolgener; Christopher Carlein; Chantal Hof; Renping Zhao; Shandong Ye; Eva C Schwarz; Dirk Brenner; Leticia Prates Roma; Bin Qu
Journal:  Front Immunol       Date:  2021-06-25       Impact factor: 7.561
  2 in total

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