Julia DiLabio1, Jill G Zwicker2,3, Rebecca Sherlock4, Sibasis Daspal5, Prakesh S Shah1,6, Vibhuti Shah7,8. 1. Division of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada. 2. Department of Occupational Science & Occupational Therapy and Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. 3. BC Children's Hospital Research Institute, Vancouver, BC, Canada. 4. Division of Neonatology, Surrey Memorial Hospital, Surrey, BC, Canada. 5. Division of Neonatology, Royal University Hospital, Saskatoon, SK, Canada. 6. Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada. 7. Division of Neonatology, Department of Paediatrics, University of Toronto, Toronto, ON, Canada. vibhuti.shah@sinaihealth.ca. 8. Department of Paediatrics, Mount Sinai Hospital, Toronto, ON, Canada. vibhuti.shah@sinaihealth.ca.
Abstract
OBJECTIVE: The objective of this study is to assess the impact of maternal age on neurodevelopmental (ND) outcomes of infants < 29 weeks gestational age (GA) at 18-24 months. STUDY DESIGN: A retrospective cohort study of preterm infants < 29 weeks GA admitted to Canadian tertiary NICUs was performed. The primary outcome was a composite of death or ND impairment (NDI)/significant NDI (sNDI) at 18-24 months. Association between maternal age and outcome was assessed across maternal age groups (15-19, 20-34, 35-39 and ≥40 years) using logistic regression after adjusting for confounders. RESULTS: Of 3691 eligible infants, 2652 with complete data were included in the analysis. Significant differences in maternal characteristics existed across age groups. The only difference in neonatal characteristics was the incidence of bronchopulmonary dysplasia (p < 0.01). There was no association between maternal age and death or NDI/sNDI after controlling for confounders. CONCLUSION: Maternal age is not associated with differences in NDI/sNDI rates among Canadian preterm infants < 29 weeks GA.
OBJECTIVE: The objective of this study is to assess the impact of maternal age on neurodevelopmental (ND) outcomes of infants < 29 weeks gestational age (GA) at 18-24 months. STUDY DESIGN: A retrospective cohort study of preterm infants < 29 weeks GA admitted to Canadian tertiary NICUs was performed. The primary outcome was a composite of death or ND impairment (NDI)/significant NDI (sNDI) at 18-24 months. Association between maternal age and outcome was assessed across maternal age groups (15-19, 20-34, 35-39 and ≥40 years) using logistic regression after adjusting for confounders. RESULTS: Of 3691 eligible infants, 2652 with complete data were included in the analysis. Significant differences in maternal characteristics existed across age groups. The only difference in neonatal characteristics was the incidence of bronchopulmonary dysplasia (p < 0.01). There was no association between maternal age and death or NDI/sNDI after controlling for confounders. CONCLUSION: Maternal age is not associated with differences in NDI/sNDI rates among Canadian preterm infants < 29 weeks GA.
Authors: B R Vohr; L L Wright; A M Dusick; L Mele; J Verter; J J Steichen; N P Simon; D C Wilson; S Broyles; C R Bauer; V Delaney-Black; K A Yolton; B E Fleisher; L A Papile; M D Kaplan Journal: Pediatrics Date: 2000-06 Impact factor: 7.124
Authors: Eva S Potharst; Aleid G van Wassenaer; Bregje A Houtzager; Janeline W P van Hus; Bob F Last; Joke H Kok Journal: J Pediatr Date: 2011-02-24 Impact factor: 4.406
Authors: Susan R Hintz; Douglas E Kendrick; Barbara J Stoll; Betty R Vohr; Avroy A Fanaroff; Edward F Donovan; W Kenneth Poole; Martin L Blakely; Linda Wright; Rosemary Higgins Journal: Pediatrics Date: 2005-03 Impact factor: 7.124
Authors: Amélie Boutin; Sarka Lisonkova; Giulia M Muraca; Neda Razaz; Shiliang Liu; Michael S Kramer; K S Joseph Journal: PLoS One Date: 2021-06-30 Impact factor: 3.240