Wei Wei1,2, Patrick F Chinnery3,4. 1. Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK. 2. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. 3. Department of Clinical Neurosciences, School of Clinical Medicine, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk. 4. Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK. pfc25@cam.ac.uk.