Literature DB >> 32693765

Cellular and Functional Effects of Insulin Based Therapies and Exercise on Endothelium.

Melissa A Luse1, Emily M Heiston1, Steven K Malin1, Brant E Isakson1.   

Abstract

Endothelial dysfunction is a hallmark of type 2 diabetes that can have severe consequences on vascular function, including hypertension and changes in blood flow, as well as exercise performance. Because endothelium is also the barrier for insulin movement into tissues, it acts as a gatekeeper for transport and glucose uptake. For this reason, endothelial dysfunction is a tempting area for pharmacological and/or exercise intervention with insulin-based therapies. In this review, we describe the current state of drugs that can be used to treat endothelial dysfunction in type 2 diabetes and diabetes-related diseases (e.g., obesity) at the molecular levels, and also discuss their role in exercise. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

Entities:  

Keywords:  Endothelial dysfunction; exercise; hypertension; insulin; pharmacological; vascular function

Mesh：

Substances：

Year:  2020        PMID： 32693765      PMCID： PMC8011202          DOI： 10.2174/1381612826666200721002735

Source DB:  PubMed          Journal:  Curr Pharm Des        ISSN： 1381-6128            Impact factor:   3.116


  83 in total

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Authors:  Zhenqi Liu; Jia Liu; Linda A Jahn; Dale E Fowler; Eugene J Barrett
Journal:  J Clin Endocrinol Metab       Date:  2009-06-30       Impact factor: 5.958

2.  A 7-d exercise program increases high-molecular weight adiponectin in obese adults.

Authors:  Karen R Kelly; Alecia Blaszczak; Jacob M Haus; Aimee Patrick-Melin; Ciaran E Fealy; Thomas P J Solomon; Michael I Kalinski; John P Kirwan
Journal:  Med Sci Sports Exerc       Date:  2012-01       Impact factor: 5.411

Review 3.  Insulin Therapy Increases Cardiovascular Risk in Type 2 Diabetes.

Authors:  Mary E Herman; James H O'Keefe; David S H Bell; Stanley S Schwartz
Journal:  Prog Cardiovasc Dis       Date:  2017-09-25       Impact factor: 8.194

4.  Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.

Authors:  Matteo Ottolini; Kwangseok Hong; Eric L Cope; Zdravka Daneva; Leon J DeLalio; Jennifer D Sokolowski; Corina Marziano; Nhiem Y Nguyen; Joachim Altschmied; Judith Haendeler; Scott R Johnstone; Mohammad Y Kalani; Min S Park; Rakesh P Patel; Wolfgang Liedtke; Brant E Isakson; Swapnil K Sonkusare
Journal:  Circulation       Date:  2020-02-03       Impact factor: 29.690

Review 5.  Vascular protective effects by activation of nuclear receptor PPARgamma.

Authors:  Shu Wakino; Ronald E Law; Willa A Hsueh
Journal:  J Diabetes Complications       Date:  2002 Jan-Feb       Impact factor: 2.852

6.  Role of AMP-activated protein kinase in mechanism of metformin action.

Authors:  G Zhou; R Myers; Y Li; Y Chen; X Shen; J Fenyk-Melody; M Wu; J Ventre; T Doebber; N Fujii; N Musi; M F Hirshman; L J Goodyear; D E Moller
Journal:  J Clin Invest       Date:  2001-10       Impact factor: 14.808

7.  Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels.

Authors:  G L King; S M Buzney; C R Kahn; N Hetu; S Buchwald; S G Macdonald; L I Rand
Journal:  J Clin Invest       Date:  1983-04       Impact factor: 14.808

8.  Free radicals mediate endothelial cell dysfunction caused by elevated glucose.

Authors:  B Tesfamariam; R A Cohen
Journal:  Am J Physiol       Date:  1992-08

Review 9.  Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk.

Authors:  Steven K Malin; Barry Braun
Journal:  Exerc Sport Sci Rev       Date:  2016-01       Impact factor: 6.230

10.  Impact of Short-Term Continuous and Interval Exercise Training on Endothelial Function and Glucose Metabolism in Prediabetes.

Authors:  Steven K Malin; Nicole M Gilbertson; Natalie Z M Eichner; Emily Heiston; Stephanie Miller; Arthur Weltman
Journal:  J Diabetes Res       Date:  2019-12-28       Impact factor: 4.011
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  2 in total

Review 1.  Issues on Trainability.

Authors:  Zsolt Radak; Albert W Taylor
Journal:  Front Physiol       Date:  2022-01-24       Impact factor: 4.566

Review 2.  Adipose Tissue-Endothelial Cell Interactions in Obesity-Induced Endothelial Dysfunction.

Authors:  Manna Li; Ming Qian; Kathy Kyler; Jian Xu
Journal:  Front Cardiovasc Med       Date:  2021-07-01
  2 in total

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