| Literature DB >> 32692466 |
Mao-Yun Lyu1, Zhuliang Zhong1, Vanessa Kar-Yan Lo2, Henry N C Wong3,1, Xiao-Shui Peng3,1.
Abstract
The total synthesis of cryptotrione (1) was enabled by substrate-controlled diastereoselective construction of the bicyclo[3.1.0]hexene framework through platinum-catalyzed enyne cycloisomerization and Lewis acid induced polyene cyclization to construct the abietane-type tricyclic diterpene skeleton. The stereogenic tertiary carbon center in the side chain was installed in a diastereodivergent manner by conjugate addition reactions.Entities:
Keywords: cyclization; enynes; isomerization; terpenoids; total synthesis
Year: 2020 PMID： 32692466 DOI： 10.1002/anie.202009255
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336