Ahmet Gürdal1, Kudret Keskin2, Mutlu Çağan Sümerkan2, Gökhan Çetinkal2, Hakan Kilci2, Şükrü Çetin2, Kadriye Orta Kılıçkesmez2. 1. Department of Cardiology, University of Health Sciences, Sisli Hamidiye Etfal Education and Research Hospital, 34360, Sisli/Istanbul, Turkey. gurdal27@hotmail.com. 2. Department of Cardiology, University of Health Sciences, Sisli Hamidiye Etfal Education and Research Hospital, 34360, Sisli/Istanbul, Turkey.
Abstract
PURPOSE: Contemporary studies assessing outcomes in octogenarian patients presenting with ST-segment elevation myocardial infarction (STEMI) and infection are scarce. This study investigated the impact and prognostic value of infection on long-term mortality in octogenarian patients with STEMI. METHODS: A total of 1564 patients admitted with STEMI between May 2015 and September 2019 were retrospectively analyzed, and 110 octogenarians were identified and included. Predictors of mortality were determined by multivariate Cox regression analysis. Survival curves were generated using the Kaplan-Meier method. RESULTS: The mean age of the patients was 85 ± 4 years, and 58 (52%) were male. Median follow-up was 41 months. Patients with infection had higher rates of in-hospital (16.4% vs. 8.2%, p = 0.001) and long-term (33.6% vs. 20%, p = 0.001) mortality. Multivariate Cox regression analysis revealed that infection (HR 3.16; 95% CI 1.52-6.59; p = 0.002) and C-reactive protein levels (HR 0.99; 95% CI 0.98-1.00; p = 0.042) were independent predictors of mortality in patients with infection. Kaplan-Meier analysis also showed that patients with infection had a significantly higher mortality rate (p < 0.001). CONCLUSION: Infection is an independent predictor of long-term mortality in octogenarian patients with STEMI.
PURPOSE: Contemporary studies assessing outcomes in octogenarian patients presenting with ST-segment elevation myocardial infarction (STEMI) and infection are scarce. This study investigated the impact and prognostic value of infection on long-term mortality in octogenarian patients with STEMI. METHODS: A total of 1564 patients admitted with STEMI between May 2015 and September 2019 were retrospectively analyzed, and 110 octogenarians were identified and included. Predictors of mortality were determined by multivariate Cox regression analysis. Survival curves were generated using the Kaplan-Meier method. RESULTS: The mean age of the patients was 85 ± 4 years, and 58 (52%) were male. Median follow-up was 41 months. Patients with infection had higher rates of in-hospital (16.4% vs. 8.2%, p = 0.001) and long-term (33.6% vs. 20%, p = 0.001) mortality. Multivariate Cox regression analysis revealed that infection (HR 3.16; 95% CI 1.52-6.59; p = 0.002) and C-reactive protein levels (HR 0.99; 95% CI 0.98-1.00; p = 0.042) were independent predictors of mortality in patients with infection. Kaplan-Meier analysis also showed that patients with infection had a significantly higher mortality rate (p < 0.001). CONCLUSION:Infection is an independent predictor of long-term mortality in octogenarian patients with STEMI.
Authors: Dharam J Kumbhani; P Gabriel Steg; Christopher P Cannon; Kim A Eagle; Sidney C Smith; Kevin Crowley; Shinya Goto; E Magnus Ohman; George L Bakris; Todd S Perlstein; Scott Kinlay; Deepak L Bhatt Journal: Eur Heart J Date: 2012-11-09 Impact factor: 29.983
Authors: Robert F Storey; Stefan K James; Agneta Siegbahn; Christoph Varenhorst; Claes Held; Joseph Ycas; Steen E Husted; Christopher P Cannon; Richard C Becker; Ph Gabriel Steg; Nils Åsenblad; Lars Wallentin Journal: Platelets Date: 2013-10-15 Impact factor: 3.862