Literature DB >> 32684845

Correction to: Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization.

Rustelle Janse van Vuuren1, Mandie Botes1,2, Tamarin Jurgens1, Anna Margaretha Joubert1, Iman van den Bout1,2.   

Abstract

[This corrects the article DOI: 10.1186/s12935-018-0719-4.].
© The Author(s) 2020.

Entities:  

Year:  2020        PMID: 32684845      PMCID: PMC7359456          DOI: 10.1186/s12935-020-01408-3

Source DB:  PubMed          Journal:  Cancer Cell Int        ISSN: 1475-2867            Impact factor:   5.722


Correction to: Cancer Cell Int (2019) 19:1 10.1186/s12935-018-0719-4

Following publication of the original article [1], the authors notified us that the graph presented in Figure 3a is the same as Figure 2a in the published manuscript. Figure 3 below represents the true migration values achieved for cells blocked in interphase and treated with the different compounds.
Fig. 3

Migration of interphase arrested cells is inhibited by ESE-15-one and ESE-one exposure. a MDA-MB-231 cells were first blocked in G1/S by exposure to thymidine before cell free zones were generated and cells were exposed to 0.2% DMSO, 0.5 μM ESE-15-one or 0.5 μM ESE-one. Cell migration into the cell-free zone was quantified after 18 h. The graph represents the average of at least three repeats with error bars representing SEM. *P < 0.001 in t-test comparison with DMSO-treated cells. b Light microscopy images of cell migration assays showing interphase cells at time 0 h and after 18 h treated with DMSO, ESE-15-one or ESE-one. Scale bar is 400 μm

Migration of interphase arrested cells is inhibited by ESE-15-one and ESE-one exposure. a MDA-MB-231 cells were first blocked in G1/S by exposure to thymidine before cell free zones were generated and cells were exposed to 0.2% DMSO, 0.5 μM ESE-15-one or 0.5 μM ESE-one. Cell migration into the cell-free zone was quantified after 18 h. The graph represents the average of at least three repeats with error bars representing SEM. *P < 0.001 in t-test comparison with DMSO-treated cells. b Light microscopy images of cell migration assays showing interphase cells at time 0 h and after 18 h treated with DMSO, ESE-15-one or ESE-one. Scale bar is 400 μm Specifically, blocked cells treated with DMSO closed 35% of the wound while ESE-15-one reduced that to 23% and ESE one reduced this to 13%. T tests show statistical significance.
  1 in total

1.  Novel sulphamoylated 2-methoxy estradiol derivatives inhibit breast cancer migration by disrupting microtubule turnover and organization.

Authors:  Rustelle Janse van Vuuren; Mandie Botes; Tamarin Jurgens; Anna Margaretha Joubert; Iman van den Bout
Journal:  Cancer Cell Int       Date:  2019-01-03       Impact factor: 5.722

  1 in total

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