Xuesong Gao1, Di Yang2, Zheng Yuan3, Yijin Zhang4, Hongjie Li5, Ping Gao6, Xiaomin Liu7, Wenshan Zhao8, Te Xiao9, Yanlin Guan10, Guiju Gao11, Xuefei Duan12. 1. Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. gaoxuesong@ccmu.edu.cn. 2. Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China. yadio25184@sina.com. 3. Department of Orthopedics, Beijing Ditan Hospital, Capital Medical University, Beijing, China. ben_nk@139.com. 4. Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. drzhang2012@126.com. 5. Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. asd24418832@163.com. 6. Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. gaoping_206@163.com. 7. Department of Oncology, Beijing Ditan Hospital, Capital Medical University, Beijing, China. 2318082806@qq.com. 8. Center of Liver Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China. zhaowenshan1989@126.com. 9. Department of Neurosurgery, Beijing Ditan Hospital, Capital Medical University, Beijing, China. 1845212686@qq.com. 10. Division of Disease Control, Beijing Ditan Hospital, Capital Medical University, Beijing, China. steven_kao@126.com. 11. Center of Infectious Disease, Beijing Ditan Hospital, Capital Medical University, Beijing, China. guiju.gao@163.com. 12. Department of General Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, China. duanxuefei@vip.sina.com.
Abstract
INTRODUCTION: An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. This study aimed to analyze the clinical and epidemiologic characteristics of patients with COVID-19 to better differentiate the suspected patients in Beijing, China. METHODOLOGY: This was a retrospective, single-center study. Clinical and epidemiologic data were collected from suspected patients with COVID-19 admitted to Beijing Ditan Hospital from January 29 to February 21, 2020. RESULTS: One hundred and six patients (60 males and 46 females, median age 36 years) were enrolled. Thirty-six patients were ultimately laboratory confirmed. Fifty-three were excluded from the diagnosis of COVID-19. The remaining 17 patients were highly suspected, although their nucleic acid tests were repeatedly negative. The confirmed patients and highly suspected patients had a significantly higher proportion of epidemiologic history than the excluded patients (P < 0.001). There was no significant difference in clinical symptoms or the underlying diseases among the three groups. The confirmed patients had a higher frequency of lymphopenia and eosinopenia than the highly suspected and excluded patients. Chest computed tomography scans showed bilateral lung involvement, and ground-glass opacity was more likely observed in the confirmed patients. CONCLUSION: The clinical features of the confirmed patients with COVID-19 were insufficient for early diagnosis of COVID-19. The epidemiologic history was of great significance in the early diagnosis of COVID-19. More sensitive diagnostic methods are needed to aid the differential diagnosis of suspected patients with COVID-19. Copyright (c) 2020 Xuesong Gao, Di Yang, Zheng Yuan, Yijin Zhang, Hongjie Li, Ping Gao, Xiaomin Liu, Wenshan Zhao, Te Xiao, Yanlin Guan, Guiju Gao, Xuefei Duan.
INTRODUCTION: An outbreak of coronavirus disease 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. This study aimed to analyze the clinical and epidemiologic characteristics of patients with COVID-19 to better differentiate the suspected patients in Beijing, China. METHODOLOGY: This was a retrospective, single-center study. Clinical and epidemiologic data were collected from suspected patients with COVID-19 admitted to Beijing Ditan Hospital from January 29 to February 21, 2020. RESULTS: One hundred and six patients (60 males and 46 females, median age 36 years) were enrolled. Thirty-six patients were ultimately laboratory confirmed. Fifty-three were excluded from the diagnosis of COVID-19. The remaining 17 patients were highly suspected, although their nucleic acid tests were repeatedly negative. The confirmed patients and highly suspected patients had a significantly higher proportion of epidemiologic history than the excluded patients (P < 0.001). There was no significant difference in clinical symptoms or the underlying diseases among the three groups. The confirmed patients had a higher frequency of lymphopenia and eosinopenia than the highly suspected and excluded patients. Chest computed tomography scans showed bilateral lung involvement, and ground-glass opacity was more likely observed in the confirmed patients. CONCLUSION: The clinical features of the confirmed patients with COVID-19 were insufficient for early diagnosis of COVID-19. The epidemiologic history was of great significance in the early diagnosis of COVID-19. More sensitive diagnostic methods are needed to aid the differential diagnosis of suspected patients with COVID-19. Copyright (c) 2020 Xuesong Gao, Di Yang, Zheng Yuan, Yijin Zhang, Hongjie Li, Ping Gao, Xiaomin Liu, Wenshan Zhao, Te Xiao, Yanlin Guan, Guiju Gao, Xuefei Duan.