Xiaohong Jin1, Huiwen Xie1, Xiaoman Liu1, Qiuyan Shen2, Ziheng Wang3, Haiyan Hao4, Yan Gu5. 1. Department of Cancer Chemotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, People's Republic of China. 2. Department of Neurosurgery, Wuxi Clinical College of Anhui Medical University, 904th Hospital of Joint Logistic Support Force of PLA, Wuxi, Jiangsu 214044, People's Republic of China. 3. Department of Clinical Biobank, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, People's Republic of China; Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, People's Republic of China. 4. Department of Outpatients, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, People's Republic of China. 5. Department of Cancer Chemotherapy, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226000, People's Republic of China. Electronic address: gy5525066@163.com.
Abstract
BACKGROUND: Diffuse gliomas are the most prevalent primary brain tumors. The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases provide evidence of the relationships between gliomas and altered molecular pathways. In glioma pathogenesis, the microenvironment has emerged as a potential indicator of tumor progression. METHODS: We investigated and confirmed the role of RELT-like 1 (RELL1) oncogene in glioblastoma and low-grade glioma by data mining large cohorts of TCGA and the CGGA. Correlations between immune cells and RELL1 were verified using the CIBERSORT algorithm. RESULTS: Our analysis revealed that RELL1 expression was much higher in grade-dependent glioma patients with poor prognosis. Comparable prognostic values for isocitrate dehydrogenase 1 (IDH1) and RELL1 were observed during in-depth analyses of the integrated correlations. Moreover, RELL1 was found to be associated with numerous tumor-infiltrating immune cells in glioma-affected patients. CONCLUSION: We conclude that RELL1 might serve as a potential therapeutic target or prognostic marker in glioblastoma and diffuse glioma cases.
BACKGROUND: Diffuse gliomas are the most prevalent primary brain tumors. The Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) databases provide evidence of the relationships between gliomas and altered molecular pathways. In glioma pathogenesis, the microenvironment has emerged as a potential indicator of tumor progression. METHODS: We investigated and confirmed the role of RELT-like 1 (RELL1) oncogene in glioblastoma and low-grade glioma by data mining large cohorts of TCGA and the CGGA. Correlations between immune cells and RELL1 were verified using the CIBERSORT algorithm. RESULTS: Our analysis revealed that RELL1 expression was much higher in grade-dependent gliomapatients with poor prognosis. Comparable prognostic values for isocitrate dehydrogenase 1 (IDH1) and RELL1 were observed during in-depth analyses of the integrated correlations. Moreover, RELL1 was found to be associated with numerous tumor-infiltrating immune cells in glioma-affected patients. CONCLUSION: We conclude that RELL1 might serve as a potential therapeutic target or prognostic marker in glioblastoma and diffuse glioma cases.
Authors: John K Cusick; Yasmeen Alhomsy; Stephanie Wong; George Talbott; Vladimir N Uversky; Cara Hart; Nazila Hejazi; Aaron T Jacobs; Yihui Shi Journal: Biochem Biophys Rep Date: 2020-12-15