Anika A H Alvanzo1, Carla L Storr2, Beth Reboussin3, Kerry M Green4, Ramin Mojtabai5, Lareina N La Flair6, Bernadette A Cullen5, Ryoko Susukida7, Marissa Seamans8, Rosa M Crum9. 1. Divisions of General Internal Medicine and Addiction Medicine, Johns Hopkins University School of Medicine, 5200 Eastern Avenue, MFL- East Tower, Room E650, Baltimore, MD, 21224, USA. Electronic address: aalvanzo.ucg@gmail.com. 2. Department of Family and Community Health, University of Maryland School of Nursing, Baltimore, MD, 21201, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, 21205, USA. 3. Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA. 4. Department of Behavioral and Community Health, University of Maryland School of Public Health, College Park, MD, 20742, USA. 5. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA. 6. Research and Data Analysis Division, Washington State Department of Social and Health Services Olympia, WA, 98501, USA. 7. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, 21205, USA. 8. Department of Epidemiology, UCLA Fielding School of Public Health Los Angeles, CA, 90025, USA. 9. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health Baltimore, MD, 21205, USA.
Abstract
BACKGROUND: Adverse childhood experiences (ACEs) are associated with a number of medical comorbidities. However, there is a paucity of data on the role ACEs play in transitions in stages of alcohol involvement. OBJECTIVE: To examine the association between ACEs and transitions in alcohol problems progression and regression between No Problems, Moderate Problems and Severe Problems stages. PARTICIPANTS AND SETTING: Data from 14,363 male and 19,774 female participants in Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). METHODS: We used latent transition analysis (LTA) with propensity score adjustment to estimate the odds of transitioning across stages of alcohol involvement, between waves, based on the number of types of ACEs experienced. We hypothesized that ACEs would be associated with increased risk of progression and decreased risk of regression. RESULTS: ACEs were associated with progression to higher alcohol involvement stages, with greatest likelihood of progression from No Problems to Severe Problems for those reporting ≥3 ACEs (males: aOR = 4.78 [CI (1.84-12.44)]; females: aOR = 3.81 [CI (1.69-8.57)]). ACEs were also associated with decreased odds of regression to less problematic alcohol involvement stages, with some distinctive patterns of associations in males and in females. CONCLUSIONS: This study suggests that ACEs impact transitions in alcohol involvement in both males and females, affecting both progression and regression. The association is magnified for those with multiple types of ACE exposures. These results highlight the need for prevention, early identification and intervention to mitigate the risks associated with childhood maltreatment.
BACKGROUND: Adverse childhood experiences (ACEs) are associated with a number of medical comorbidities. However, there is a paucity of data on the role ACEs play in transitions in stages of alcohol involvement. OBJECTIVE: To examine the association between ACEs and transitions in alcohol problems progression and regression between No Problems, Moderate Problems and Severe Problems stages. PARTICIPANTS AND SETTING: Data from 14,363 male and 19,774 female participants in Waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). METHODS: We used latent transition analysis (LTA) with propensity score adjustment to estimate the odds of transitioning across stages of alcohol involvement, between waves, based on the number of types of ACEs experienced. We hypothesized that ACEs would be associated with increased risk of progression and decreased risk of regression. RESULTS: ACEs were associated with progression to higher alcohol involvement stages, with greatest likelihood of progression from No Problems to Severe Problems for those reporting ≥3 ACEs (males: aOR = 4.78 [CI (1.84-12.44)]; females: aOR = 3.81 [CI (1.69-8.57)]). ACEs were also associated with decreased odds of regression to less problematic alcohol involvement stages, with some distinctive patterns of associations in males and in females. CONCLUSIONS: This study suggests that ACEs impact transitions in alcohol involvement in both males and females, affecting both progression and regression. The association is magnified for those with multiple types of ACE exposures. These results highlight the need for prevention, early identification and intervention to mitigate the risks associated with childhood maltreatment.
Authors: Jennifer C Elliott; Malka Stohl; Melanie M Wall; Katherine M Keyes; Andrew E Skodol; Nicholas R Eaton; Dvora Shmulewitz; Renee D Goodwin; Bridget F Grant; Deborah S Hasin Journal: Addiction Date: 2016-02-18 Impact factor: 6.526
Authors: H L MacMillan; J E Fleming; D L Streiner; E Lin; M H Boyle; E Jamieson; E K Duku; C A Walsh; M Y Wong; W R Beardslee Journal: Am J Psychiatry Date: 2001-11 Impact factor: 18.112
Authors: Laura Ramo-Fernández; Christina Boeck; Alexandra M Koenig; Katharina Schury; Elisabeth B Binder; Harald Gündel; Jöerg M Fegert; Alexander Karabatsiakis; Iris-Tatjana Kolassa Journal: Sci Rep Date: 2019-04-18 Impact factor: 4.379
Authors: Rosa M Crum; Ramin Mojtabai; Samuel Lazareck; James M Bolton; Jennifer Robinson; Jitender Sareen; Kerry M Green; Elizabeth A Stuart; Lareina La Flair; Anika A H Alvanzo; Carla L Storr Journal: JAMA Psychiatry Date: 2013-07 Impact factor: 21.596
Authors: Sarah Gerhardt; Katharina Eidenmueller; Sabine Hoffmann; Nina K Bekier; Patrick Bach; Derik Hermann; Anne Koopmann; Wolfgang H Sommer; Falk Kiefer; Sabine Vollstädt-Klein Journal: Front Psychiatry Date: 2022-04-14 Impact factor: 5.435