Menghua Wang1, Zhongyu Jian1,2, Yucheng Ma1, Xi Jin1, Hong Li1, Kunjie Wang3. 1. Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. 2. West China Biomedical Big Data Center, Sichuan University, Chengdu, People's Republic of China. 3. Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, People's Republic of China. wangkj@scu.edu.cn.
Abstract
INTRODUCTION AND HYPOTHESIS: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of percutaneous tibial nerve stimulation (PTNS) for the treatment of overactive bladder (OAB) syndrome. METHODS: PubMed, Embase, Web of Science and Cochrane Library were searched systematically to identify all the relevant studies. Void frequency per day, nocturia frequency per day, urgency episodes per day, incontinence episodes per day, urodynamic values, success rate and side effects, etc., were extracted from the included studies and analyzed. RESULTS: Twenty-eight studies with 2461 patients in total were included. Results showed that there was a significant clinical effect on the voiding frequency per day (MD = -2.48; 95% CI -3.19, -1.76; P < 0.001), nocturia frequency per day (MD = -1.57; 95% CI -2.16, -0.99; P < 0.001), urgency episodes per day (MD = -2.20; 95% CI -3.77, -0.62; P = 0.006), incontinence episodes per day (MD = -1.37; 95% CI -1.71, -1.02; P < 0.001), maximum cystometric capacity (MD = 63.76; 95% CI 31.90, 95.61; P < 0.001) and compliance (MD = 7.62; 95% CI 0.61, 14.63; P = 0.033). The pooled success rate was 0.68 (95% CI 0.59, 0.78). The major complication was the pain at the puncture site, but the incidence was low. CONCLUSIONS: PTNS is effective and safe in treating OAB symptoms.
INTRODUCTION AND HYPOTHESIS: This systematic review and meta-analysis aimed to evaluate the efficacy and safety of percutaneous tibial nerve stimulation (PTNS) for the treatment of overactive bladder (OAB) syndrome. METHODS: PubMed, Embase, Web of Science and Cochrane Library were searched systematically to identify all the relevant studies. Void frequency per day, nocturia frequency per day, urgency episodes per day, incontinence episodes per day, urodynamic values, success rate and side effects, etc., were extracted from the included studies and analyzed. RESULTS: Twenty-eight studies with 2461 patients in total were included. Results showed that there was a significant clinical effect on the voiding frequency per day (MD = -2.48; 95% CI -3.19, -1.76; P < 0.001), nocturia frequency per day (MD = -1.57; 95% CI -2.16, -0.99; P < 0.001), urgency episodes per day (MD = -2.20; 95% CI -3.77, -0.62; P = 0.006), incontinence episodes per day (MD = -1.37; 95% CI -1.71, -1.02; P < 0.001), maximum cystometric capacity (MD = 63.76; 95% CI 31.90, 95.61; P < 0.001) and compliance (MD = 7.62; 95% CI 0.61, 14.63; P = 0.033). The pooled success rate was 0.68 (95% CI 0.59, 0.78). The major complication was the pain at the puncture site, but the incidence was low. CONCLUSIONS:PTNS is effective and safe in treating OAB symptoms.
Authors: Eric Chung; Dominic Lee; Johan Gani; Michael Gillman; Christopher Maher; Janelle Brennan; Lydia Johns Putra; Laura Ahmad; Lewis Lw Chan Journal: Med J Aust Date: 2018-01-15 Impact factor: 7.738
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