Hassiba Benbaibeche1,2, Abdenour Bounihi3,4, Elhadj Ahmed Koceir3. 1. Département des Sciences de la Nature et de la Vie, Faculté des Sciences, Université D'Alger, Algiers, Algeria. benbaibecheh@yahoo.fr. 2. Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria. benbaibecheh@yahoo.fr. 3. Bioenergetics and Intermediary Metabolism team, Biology and Organisms Physiology laboratory, Biological Sciences Faculty, University of Sciences and Technology Houari Boumediene (USTHB), El Alia, Bab Ezzouar, 16123, Algiers, Algeria. 4. Department of Second Cycle, Ecole Supérieure des Sciences de l'Aliment et des Industries Agroalimentaires, Algiers, Algeria.
Abstract
BACKGROUND: Uncontrolled eating (UE) showed important relationships with the development of obesity. Homeostatic regulations of feeding and energy balance, as well as hedonic eating, are regulated by leptin. AIMS: The aims of this study were (1) to assess eating behaviors of Algerian adults as measured by the 51-item eating inventory; we also evaluate changes in the Three-Factor Eating Questionnaire (TFEQ) scores according to the body mass index (BMI) category; (2) to examine the association between the scores of the three TFEQ factors and the BMI values of the participants; and (3) to examine whether leptin concentrations are associated with eating behavior. Our hypothesis is that participants with obesity and high concentrations of leptin might display uncontrolled eating behavior. METHODS: The subjects were 190 participants (60 obese, 60 overweight, and 70 lean subjects). The eating behavior was measured by using the 51-item eating inventory. Serum insulin concentrations were assessed by radioimmunoassay and were used to calculate homeostasis model assessment (HOMA). Serum leptin was quantified by the enzyme-linked immunosorbent assay (ELISA). RESULTS: Obese and overweight subjects showed hyperphagic behavior, i.e., uncontrolled eating. The logistic regression analysis showed an effect of leptin, HOMA, uncontrolled eating, and emotional eating on BMI. Leptin levels were associated with the uncontrolled eating and influenced by insulin sensitivity. CONCLUSIONS: The uncontrolled eating reflects hyperphagic eating behavior in obese and overweight subjects. Coexistence of uncontrolled eating and high level of leptin demonstrates a state of leptin resistance resulting in an inability to detect satiety. High circulating leptin can be considered a potential biomarker of uncontrolled eating.
BACKGROUND: Uncontrolled eating (UE) showed important relationships with the development of obesity. Homeostatic regulations of feeding and energy balance, as well as hedonic eating, are regulated by leptin. AIMS: The aims of this study were (1) to assess eating behaviors of Algerian adults as measured by the 51-item eating inventory; we also evaluate changes in the Three-Factor Eating Questionnaire (TFEQ) scores according to the body mass index (BMI) category; (2) to examine the association between the scores of the three TFEQ factors and the BMI values of the participants; and (3) to examine whether leptin concentrations are associated with eating behavior. Our hypothesis is that participants with obesity and high concentrations of leptin might display uncontrolled eating behavior. METHODS: The subjects were 190 participants (60 obese, 60 overweight, and 70 lean subjects). The eating behavior was measured by using the 51-item eating inventory. Serum insulin concentrations were assessed by radioimmunoassay and were used to calculate homeostasis model assessment (HOMA). Serum leptin was quantified by the enzyme-linked immunosorbent assay (ELISA). RESULTS:Obese and overweight subjects showed hyperphagic behavior, i.e., uncontrolled eating. The logistic regression analysis showed an effect of leptin, HOMA, uncontrolled eating, and emotional eating on BMI. Leptin levels were associated with the uncontrolled eating and influenced by insulin sensitivity. CONCLUSIONS: The uncontrolled eating reflects hyperphagic eating behavior in obese and overweight subjects. Coexistence of uncontrolled eating and high level of leptin demonstrates a state of leptin resistance resulting in an inability to detect satiety. High circulating leptin can be considered a potential biomarker of uncontrolled eating.
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