OBJECTIVES: We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, immunocompromised, and chronically ill children. METHODS: We conducted a single-center retrospective cohort study of hospitalized children aged younger than 22 years with COVID-19 infection at Steven and Alexandra Cohen Children's Medical Center at Northwell Health. Cases were identified from patients with fever and/or respiratory symptoms who underwent a nucleic acid amplification-based test for severe acute respiratory syndrome coronavirus 2. RESULTS: Sixty-five patients were identified. The median age was 10.3 years (interquartile range, 1.4 months to 16.3 years), with 48% of patients older than 12 years and 29% of patients younger than 60 days of age. Fever was present in 86% of patients, lower respiratory symptoms or signs in 60%, and gastrointestinal symptoms in 62%. Thirty-five percent of patients required ICU care. The white blood cell count was elevated in severe disease (P = .0027), as was the C-reactive protein level (P = .0192), compared with mild and moderate disease. Respiratory support was required in 34% of patients. Severity was lowest in infants younger than 60 days of age and highest in chronically ill children; 79% of immunocompromised children had mild disease. One death was reported. CONCLUSIONS: Among children who are hospitalized for COVID-19, most are younger than 60 days or older than 12 years of age. Children may have severe infection requiring intensive care support. The clinical course of immunocompromised patients was not more severe than that of other children. Elevated white blood cell count and C-reactive protein level are associated with greater illness severity.
OBJECTIVES: We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, immunocompromised, and chronically ill children. METHODS: We conducted a single-center retrospective cohort study of hospitalized children aged younger than 22 years with COVID-19 infection at Steven and Alexandra Cohen Children's Medical Center at Northwell Health. Cases were identified from patients with fever and/or respiratory symptoms who underwent a nucleic acid amplification-based test for severe acute respiratory syndrome coronavirus 2. RESULTS: Sixty-five patients were identified. The median age was 10.3 years (interquartile range, 1.4 months to 16.3 years), with 48% of patients older than 12 years and 29% of patients younger than 60 days of age. Fever was present in 86% of patients, lower respiratory symptoms or signs in 60%, and gastrointestinal symptoms in 62%. Thirty-five percent of patients required ICU care. The white blood cell count was elevated in severe disease (P = .0027), as was the C-reactive protein level (P = .0192), compared with mild and moderate disease. Respiratory support was required in 34% of patients. Severity was lowest in infants younger than 60 days of age and highest in chronically ill children; 79% of immunocompromised children had mild disease. One death was reported. CONCLUSIONS: Among children who are hospitalized for COVID-19, most are younger than 60 days or older than 12 years of age. Children may have severe infection requiring intensive care support. The clinical course of immunocompromised patients was not more severe than that of other children. Elevated white blood cell count and C-reactive protein level are associated with greater illness severity.
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Authors: Rebecca C Woodruff; Angela P Campbell; Christopher A Taylor; Shua J Chai; Breanna Kawasaki; James Meek; Evan J Anderson; Andy Weigel; Maya L Monroe; Libby Reeg; Erica Bye; Daniel M Sosin; Alison Muse; Nancy M Bennett; Laurie M Billing; Melissa Sutton; H Keipp Talbot; Keegan McCaffrey; Huong Pham; Kadam Patel; Michael Whitaker; Meredith L McMorrow; Fiona P Havers Journal: Pediatrics Date: 2021-12-22 Impact factor: 9.703
Authors: Teresa B Kortz; Emilia Connolly; C Lee Cohen; Rebecca E Cook; Jennifer A Jonas; Michael S Lipnick; Niranjan Kissoon Journal: Pediatr Emerg Care Date: 2021-10-01 Impact factor: 1.602
Authors: Laura A Vella; Josephine R Giles; Amy E Baxter; Derek A Oldridge; Caroline Diorio; Leticia Kuri-Cervantes; Cécile Alanio; M Betina Pampena; Jennifer E Wu; Zeyu Chen; Yinghui Jane Huang; Elizabeth M Anderson; Sigrid Gouma; Kevin O McNerney; Julie Chase; Chakkapong Burudpakdee; Jessica H Lee; Sokratis A Apostolidis; Alexander C Huang; Divij Mathew; Oliva Kuthuru; Eileen C Goodwin; Madison E Weirick; Marcus J Bolton; Claudia P Arevalo; Andre Ramos; C J Jasen; Peyton E Conrey; Samir Sayed; Heather M Giannini; Kurt D'Andrea; Nuala J Meyer; Edward M Behrens; Hamid Bassiri; Scott E Hensley; Sarah E Henrickson; David T Teachey; Michael R Betts; E John Wherry Journal: Sci Immunol Date: 2021-03-02
Authors: Florence T Bourgeois; Alba Gutiérrez-Sacristán; Mark S Keller; Molei Liu; Chuan Hong; Clara-Lea Bonzel; Amelia L M Tan; Bruce J Aronow; Martin Boeker; John Booth; Jaime Cruz Rojo; Batsal Devkota; Noelia García Barrio; Nils Gehlenborg; Alon Geva; David A Hanauer; Meghan R Hutch; Richard W Issitt; Jeffrey G Klann; Yuan Luo; Kenneth D Mandl; Chengsheng Mao; Bertrand Moal; Karyn L Moshal; Shawn N Murphy; Antoine Neuraz; Kee Yuan Ngiam; Gilbert S Omenn; Lav P Patel; Miguel Pedrera Jiménez; Neil J Sebire; Pablo Serrano Balazote; Arnaud Serret-Larmande; Andrew M South; Anastasia Spiridou; Deanne M Taylor; Patric Tippmann; Shyam Visweswaran; Griffin M Weber; Isaac S Kohane; Tianxi Cai; Paul Avillach Journal: JAMA Netw Open Date: 2021-06-01
Authors: Andi L Shane; Alice I Sato; Carol Kao; Felice C Adler-Shohet; Surabhi B Vora; Jeffery J Auletta; Sharon Nachman; Vanessa N Raabe; Kengo Inagaki; Ibukunoluwa C Akinboyo; Charles Woods; Abdulsalam O Alsulami; Mundeep K Kainth; Roberto Parulan Santos; Claudia M Espinosa; Julianne E Burns; Coleen K Cunningham; Samuel R Dominguez; Beatriz Larru Martinez; Frank Zhu; Jonathan Crews; Taito Kitano; Lisa Saiman; Karen Kotloff Journal: J Pediatric Infect Dis Soc Date: 2020-11-10 Impact factor: 3.164