Literature DB >> 32679092

Ploidy Leads a Molecular Motor to Walk Different Paths to Drug Resistance.

Alexander M Real1, William M Marsiglia1, Arvin C Dar2.   

Abstract

In this issue of Cell Chemical Biology, Pisa et al. (2020) find that haploid and diploid cells differentially develop resistance to the CENP-E inhibitor GSK923295. The results highlight the power of tumor cells to evade growth inhibition and potentially inform the design of next-generation CENP-E drugs to overcome resistance.
Copyright © 2020 Elsevier Ltd. All rights reserved.

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Year:  2020        PMID： 32679092      PMCID： PMC7751795          DOI： 10.1016/j.chembiol.2020.06.019

Source DB:  PubMed          Journal:  Cell Chem Biol        ISSN： 2451-9448            Impact factor:   8.116


  10 in total

Review 1.  The evolution of protein kinase inhibitors from antagonists to agonists of cellular signaling.

Authors:  Arvin C Dar; Kevan M Shokat
Journal:  Annu Rev Biochem       Date:  2011       Impact factor: 23.643

2.  Converting cancer therapies into cures: lessons from infectious diseases.

Authors:  Michael S Glickman; Charles L Sawyers
Journal:  Cell       Date:  2012-03-16       Impact factor: 41.582

3.  Distinct Mechanisms of Resistance to a CENP-E Inhibitor Emerge in Near-Haploid and Diploid Cancer Cells.

Authors:  Rudolf Pisa; Donovan Y Z Phua; Tarun M Kapoor
Journal:  Cell Chem Biol       Date:  2020-05-21       Impact factor: 8.116

4.  Aneuploidy acts both oncogenically and as a tumor suppressor.

Authors:  Beth A A Weaver; Alain D Silk; Cristina Montagna; Pascal Verdier-Pinard; Don W Cleveland
Journal:  Cancer Cell       Date:  2006-12-28       Impact factor: 31.743

Review 5.  Leveraging Chemotype-Specific Resistance for Drug Target Identification and Chemical Biology.

Authors:  Tarun M Kapoor; Rand M Miller
Journal:  Trends Pharmacol Sci       Date:  2017-10-13       Impact factor: 14.819

6.  Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.

Authors:  Kenneth W Wood; Latesh Lad; Lusong Luo; Xiangping Qian; Steven D Knight; Neysa Nevins; Katjusa Brejc; David Sutton; Aidan G Gilmartin; Penelope R Chua; Radhika Desai; Stephen P Schauer; Dean E McNulty; Roland S Annan; Lisa D Belmont; Carlos Garcia; Yan Lee; Melody A Diamond; Leo F Faucette; Michele Giardiniere; Shuyun Zhang; Chiu-Mei Sun; Justin D Vidal; Serge Lichtsteiner; William D Cornwell; Joel D Greshock; Richard F Wooster; Jeffrey T Finer; Robert A Copeland; Pearl S Huang; David J Morgans; Dashyant Dhanak; Gustave Bergnes; Roman Sakowicz; Jeffrey R Jackson
Journal:  Proc Natl Acad Sci U S A       Date:  2010-02-18       Impact factor: 11.205

7.  Analyzing Resistance to Design Selective Chemical Inhibitors for AAA Proteins.

Authors:  Rudolf Pisa; Tommaso Cupido; Jonathan B Steinman; Natalie H Jones; Tarun M Kapoor
Journal:  Cell Chem Biol       Date:  2019-06-27       Impact factor: 8.116

8.  The microtubule binding properties of CENP-E's C-terminus and CENP-F.

Authors:  Vivek Musinipally; Stuart Howes; Gregory M Alushin; Eva Nogales
Journal:  J Mol Biol       Date:  2013-07-25       Impact factor: 5.469

9.  The allosteric inhibitor ABL001 enables dual targeting of BCR-ABL1.

Authors:  Andrew A Wylie; Joseph Schoepfer; Wolfgang Jahnke; Sandra W Cowan-Jacob; Alice Loo; Pascal Furet; Andreas L Marzinzik; Xavier Pelle; Jerry Donovan; Wenjing Zhu; Silvia Buonamici; A Quamrul Hassan; Franco Lombardo; Varsha Iyer; Michael Palmer; Giuliano Berellini; Stephanie Dodd; Sanjeev Thohan; Hans Bitter; Susan Branford; David M Ross; Timothy P Hughes; Lilli Petruzzelli; K Gary Vanasse; Markus Warmuth; Francesco Hofmann; Nicholas J Keen; William R Sellers
Journal:  Nature       Date:  2017-03-22       Impact factor: 49.962

10.  Designing a chemical inhibitor for the AAA protein spastin using active site mutations.

Authors:  Tommaso Cupido; Rudolf Pisa; Megan E Kelley; Tarun M Kapoor
Journal:  Nat Chem Biol       Date:  2019-02-18       Impact factor: 15.040
  10 in total

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