Literature DB >> 32679052

Use of the kinetically-derived maximum dose: Opportunities for delivering 3Rs benefits.

Fiona Sewell1, Ian Kimber2, Alan R Boobis3.   

Abstract

Entities:  

Keywords:  3Rs; Dose selection; Kinetically-derived Maximum Dose (KMD); Limit dose; Maximum Tolerated Dose (MTD); Reduction; Refinement

Year:  2020        PMID： 32679052     DOI： 10.1016/j.yrtph.2020.104734

Source DB:  PubMed          Journal:  Regul Toxicol Pharmacol        ISSN： 0273-2300            Impact factor:   3.271


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  3 in total

1.  Opportunities and challenges related to saturation of toxicokinetic processes: Implications for risk assessment.

Authors:  Yu-Mei Tan; Hugh A Barton; Alan Boobis; Rachel Brunner; Harvey Clewell; Rhian Cope; Jeffrey Dawson; Jeanne Domoradzki; Peter Egeghy; Pankaj Gulati; Brandall Ingle; Nicole Kleinstreuer; Kelly Lowe; Anna Lowit; Elizabeth Mendez; David Miller; Jeffrey Minucci; James Nguyen; Alicia Paini; Monique Perron; Katherine Phillips; Hua Qian; Tharacad Ramanarayanan; Fiona Sewell; Philip Villanueva; John Wambaugh; Michelle Embry
Journal:  Regul Toxicol Pharmacol       Date:  2021-10-28       Impact factor: 3.598

Review 2.  Principles of dose-setting in toxicology studies: the importance of kinetics for ensuring human safety.

Authors:  C J Borgert; C Fuentes; L D Burgoon
Journal:  Arch Toxicol       Date:  2021-10-08       Impact factor: 5.153

Review 3.  Recommendations on dose level selection for repeat dose toxicity studies.

Authors:  Fiona Sewell; Marco Corvaro; Amanda Andrus; Jonathan Burke; George Daston; Bryan Delaney; Jeanne Domoradzki; Carole Forlini; Maia Louise Green; Thomas Hofmann; Sven Jäckel; Moung Sook Lee; Michael Temerowski; Paul Whalley; Richard Lewis
Journal:  Arch Toxicol       Date:  2022-04-29       Impact factor: 6.168
  3 in total

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