Metabolic control theory: a structural approach.

In the general framework of metabolic control theory, we describe a method of mathematical modelling that provides a way of analysing the sensitivity of a metabolic system to perturbations of the environment or of the internal state of this system. The method can be applied to any metabolic system, involving for instance conservation relationships, non-specific external parameters, etc., and leads in particular to a characterization of the control matrices and to a generalization of the summation and connectivity theorems. In this paper, we emphasize the structural characterizations and properties of the systems which depend only on the structure of the metabolic network, and not on the reaction kinetics. The advantage of this approach lies of course in the fact that the structure of the metabolic network is an invariant of the system which depends neither on the environment nor on the internal state of this system. The aim of this paper is to show the efficiency of such a structural approach.