Mohamad Allaw1, Maria Pleguezuelos-Villa2, Maria Letizia Manca1, Carla Caddeo1, Matteo Aroffu1, Amparo Nacher2,3, Octavio Diez-Sales2,3, Amparo Ruiz Saurí4, Elvira Escribano Ferrer5, Anna Maria Fadda1, Maria Manconi1. 1. Department of Scienze della Vita e dell'Ambiente, University of Cagliari, Via Ospedale 72, Cagliari, 09124, Italy. 2. Department of Pharmacy & Pharmaceutical Technology & Parasitology, University of Valencia, Burjassot, Vicente Andrés Estellés s/n, Valencia, 46100, Spain. 3. Institute of Molecular Recognition & Technological Development, Inter-University Institute from Polytechnic University of Valencia & University of Valencia, Burjassot, 46100, Spain. 4. Department of Pathology, University of Valencia, Avda Blasco Ibañez 17, Valencia, 46010, Spain. 5. Biopharmaceutics & Pharmacokinetics Unit, Institute for Nanoscience & Nanotechnology, University of Barcelona, Barcelona, 08193, Spain.
Abstract
Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.
Aim: The moisturizing properties of glycerol, the penetration enhancing capability of propylene glycol and the bioadhesive properties of mucin were combined to improve the carrier capabilities of transfersomes and the efficacy of mangiferin in the treatment of skin lesions. Materials & methods: Mangiferin was incorporated in transfersomes and glycoltransfersomes, which were also modified with mucin. The physico-chemical features were assessed, along with the efficacy against oxidative stress and skin wounds in vitro and in vivo. Results: Glycoltransfersomes promoted the deposition of mangiferin in epidermis and dermis, protected fibroblasts from oxidative stress and stimulated their proliferation. The wound healing and anti-inflammatory efficacy of glycoltransfersomes were confirmed in vivo. Conclusion: Results confirmed the potential of glycoltransfersomes in preventing/treating of skin lesions.
Authors: Ines Castangia; Maria Letizia Manca; Seyed Hadi Razavi; Amparo Nácher; Octavio Díez-Sales; José Esteban Peris; Mohamad Allaw; Maria Carmen Terencio; Iris Usach; Maria Manconi Journal: Biomedicines Date: 2022-01-12