D Gomez1, C Calderón2, A Carmona-Bayonas3, D Cacho Lavin4, M M Muñoz5, R Martinez Cabañez6, P Jimenez-Fonseca7. 1. Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, University of Pais Vasco, Pais Vasco, Avenida Roma sn, 33011, Oviedo, Spain. 2. Department of Clinical Psychology and Psychobiology, Faculty of Psychology, University of Barcelona, University of Pais Vasco, Pais Vasco, Barcelona, Spain. 3. Department of Medical Oncology, Hospital Universitario Morales Meseguer, UMU, IMI, Murcia, Spain. 4. Department of Medical Oncology, Hospital Universitario Marqués de Valdecilla, IDIVAL, Santander, Spain. 5. Department of Medical Oncology, Hospital Universitario Virgen de La Luz, Cuenca, Spain. 6. Department of Medical Oncology, Hospital Universitario Fundación Alcorcón, Madrid, Spain. 7. Department of Medical Oncology, Hospital Universitario Central de Asturias, ISPA, University of Pais Vasco, Pais Vasco, Avenida Roma sn, 33011, Oviedo, Spain. palucaji@hotmail.com.
Abstract
OBJECTIVE: To identify distinct trajectories of toxicity in colorectal cancer (CRC) patients after adjuvant chemotherapy and its impact on quality of life (QoL) and psychological symptoms. METHODS: A prospective, multicenter study was conducted in 157 patients. A latent class analysis defined the unobserved latent constructs that can be predicted as symptom clusters, considering the intensity of four types of adverse events (AEs). Patients completed EORTC-QLQ-C30, BSI-18, PDRQ-9, and DRS scales. RESULTS: Ninety-six percent had some degree of toxicity, with grades 3-4 being the most common: neurotoxicity (7.2%), hematological (13.1%), digestive (5.2%), and skin toxicity (1.4%). Three distinct latent classes were identified (high [72.5%], mild [16.9%], and low [10.6%] toxicity). Patients with high toxicity had the worst QoL scores and moderately high somatization and psychological distress scores. CONCLUSIONS: Adjuvant chemotherapy for CRC was associated with frequent toxicity that negatively impacted QoL and psychological wellbeing.
OBJECTIVE: To identify distinct trajectories of toxicity in colorectal cancer (CRC) patients after adjuvant chemotherapy and its impact on quality of life (QoL) and psychological symptoms. METHODS: A prospective, multicenter study was conducted in 157 patients. A latent class analysis defined the unobserved latent constructs that can be predicted as symptom clusters, considering the intensity of four types of adverse events (AEs). Patients completed EORTC-QLQ-C30, BSI-18, PDRQ-9, and DRS scales. RESULTS: Ninety-six percent had some degree of toxicity, with grades 3-4 being the most common: neurotoxicity (7.2%), hematological (13.1%), digestive (5.2%), and skin toxicity (1.4%). Three distinct latent classes were identified (high [72.5%], mild [16.9%], and low [10.6%] toxicity). Patients with high toxicity had the worst QoL scores and moderately high somatization and psychological distress scores. CONCLUSIONS: Adjuvant chemotherapy for CRC was associated with frequent toxicity that negatively impacted QoL and psychological wellbeing.
Authors: Christina Teng; Jordan Cohen; Sam Egger; Prunella L Blinman; Janette L Vardy Journal: Support Care Cancer Date: 2021-08-19 Impact factor: 3.603