Nada Andelic1,2, Cecilie Røe3,4, Cathrine Brunborg5, Marina Zeldovich6, Marianne Løvstad7,8, Daniel Løke7,8, Ida M Borgen3,8, Daphne C Voormolen9, Emilie I Howe3,4, Marit V Forslund3, Hilde M Dahl4,10, Nicole von Steinbuechel6. 1. Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway. nandelic@online.no. 2. Faculty of Medicine, Institute of Health and Society, Research Centre for Habilitation and Rehabilitation Models and Services (CHARM), University of Oslo, Oslo, Norway. nandelic@online.no. 3. Department of Physical Medicine and Rehabilitation, Oslo University Hospital, Oslo, Norway. 4. Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway. 5. Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway. 6. Institute of Medical Psychology and Medical Sociology, University Medical Center, Göttingen, Germany. 7. Research Department, Sunnaas Rehabilitation Hospital, Bjørnemyr, Norway. 8. Department of Psychology, Faculty of Social Sciences, University of Oslo, Oslo, Norway. 9. Department of Public Health, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. 10. Department of Child Neurology, Oslo University Hospital, Oslo, Norway.
Abstract
BACKGROUND: Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. METHODS: Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. RESULTS: Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. CONCLUSION: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.
BACKGROUND:Fatigue is one of the most commonly reported subjective symptoms following traumatic brain injury (TBI). The aims were to assess frequency of fatigue over the first 6 months after TBI, and examine whether fatigue changes could be predicted by demographic characteristics, injury severity and comorbidities. METHODS:Patients with acute TBI admitted to 65 trauma centers were enrolled in the study Collaborative European NeuroTrauma Effectiveness Research in TBI (CENTER-TBI). Subjective fatigue was measured by single item on the Rivermead Post-Concussion Symptoms Questionnaire (RPQ), administered at baseline, three and 6 months postinjury. Patients were categorized by clinical care pathway: admitted to an emergency room (ER), a ward (ADM) or an intensive care unit (ICU). Injury severity, preinjury somatic- and psychiatric conditions, depressive and sleep problems were registered at baseline. For prediction of fatigue changes, descriptive statistics and mixed effect logistic regression analysis are reported. RESULTS:Fatigue was experienced by 47% of patients at baseline, 48% at 3 months and 46% at 6 months. Patients admitted to ICU had a higher probability of experiencing fatigue than those in ER and ADM strata. Females and individuals with lower age, higher education, more severe intracranial injury, preinjury somatic and psychiatric conditions, sleep disturbance and feeling depressed postinjury had a higher probability of fatigue. CONCLUSION: A high and stable frequency of fatigue was found during the first 6 months after TBI. Specific socio-demographic factors, comorbidities and injury severity characteristics were predictors of fatigue in this study.
Entities:
Keywords:
Head injury; Longitudinal studies; Neurological disorders; Post-traumatic fatigue
Authors: Alexandra L Clark; Scott F Sorg; Kelsey Holiday; Erin D Bigler; Katherine J Bangen; Nicole D Evangelista; Mark W Bondi; Dawn M Schiehser; Lisa Delano-Wood Journal: J Head Trauma Rehabil Date: 2018 Nov/Dec Impact factor: 2.710
Authors: Diego Rivera; Sven Greving; Juan Carlos Arango-Lasprilla; Nicole von Steinbuechel; Marina Zeldovich Journal: J Clin Med Date: 2022-07-14 Impact factor: 4.964