Qing Guan1,2,3, Xiaohui Hu1,3, Ning Ma4, Hao He1,2,3, Feiyan Duan3, Xin Li5, Yuejia Luo1,2,3, Haobo Zhang1,2,3. 1. Center for Brain Disorder and Cognitive Science, Shenzhen University, Shenzhen, China. 2. Center for Neuroimaging, Shenzhen Institute of Neuroscience, Shenzhen, China. 3. School of Psychology, Shenzhen University, Shenzhen, China. 4. Center for Sleep Research, School of Psychology, South China Normal University, Guangzhou, China. 5. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, P. R. China.
Abstract
BACKGROUND: Both sleep quality and depression could affect cognitive performance in older adults. Previous studies have suggested that there are bi-directional relationships between sleep quality and depression. Possibly, the influence of sleep quality on cognition is partly mediated by depression, and vice versa. OBJECTIVE: We aimed to assess the mediation effects of sleep quality and depression on each other's relationship with various cognitive functions in non-demented older adults. METHODS: Correlations were examined among sleep quality indices, depressive severity score, and five cognitive functions in 206 cognitively normal (CN) older adults and all participants that included these CN and 40 mild cognitive impairment (MCI) individuals. We then analyzed the mediation effects for the significant cognitive correlations of sleep disturbance and depression using the bias-corrected Bootstrap method in the two populations. RESULTS: Both sleep disturbance and depression were significantly correlated with memory recall and processing speed. In CN, depression could mediate the relationships of sleep disturbance with both cognitive functions, while sleep disturbance could only mediate the relationship of depression with processing speed, but not memory recall. However, in all participants, sleep disturbance could mediate the relationships of depression with both cognitive functions. CONCLUSION: Different mediation effects in the two models in CN older adults might suggest differential mechanisms underlying the pathways from sleep disturbance and depression to various cognitive functions. The mediation results in all participants might indicate that the mechanisms underlying the pathways from sleep disturbance and depression to memory recall were different between MCI and CN older adults.
BACKGROUND: Both sleep quality and depression could affect cognitive performance in older adults. Previous studies have suggested that there are bi-directional relationships between sleep quality and depression. Possibly, the influence of sleep quality on cognition is partly mediated by depression, and vice versa. OBJECTIVE: We aimed to assess the mediation effects of sleep quality and depression on each other's relationship with various cognitive functions in non-demented older adults. METHODS: Correlations were examined among sleep quality indices, depressive severity score, and five cognitive functions in 206 cognitively normal (CN) older adults and all participants that included these CN and 40 mild cognitive impairment (MCI) individuals. We then analyzed the mediation effects for the significant cognitive correlations of sleep disturbance and depression using the bias-corrected Bootstrap method in the two populations. RESULTS: Both sleep disturbance and depression were significantly correlated with memory recall and processing speed. In CN, depression could mediate the relationships of sleep disturbance with both cognitive functions, while sleep disturbance could only mediate the relationship of depression with processing speed, but not memory recall. However, in all participants, sleep disturbance could mediate the relationships of depression with both cognitive functions. CONCLUSION: Different mediation effects in the two models in CN older adults might suggest differential mechanisms underlying the pathways from sleep disturbance and depression to various cognitive functions. The mediation results in all participants might indicate that the mechanisms underlying the pathways from sleep disturbance and depression to memory recall were different between MCI and CN older adults.
Authors: Tianyue Guan; Chao Zhang; Xuanmin Zou; Chen Chen; Li Zhou; Xiaochang Wu; Jiahu Hao Journal: Int J Environ Res Public Health Date: 2022-10-01 Impact factor: 4.614
Authors: Jieru Wang; Wen Qin; Mingli Pang; Bo Zhao; Jing Xu; Shixue Li; Fanlei Kong Journal: Int J Environ Res Public Health Date: 2022-10-05 Impact factor: 4.614