Maira L S Takemoto1, Mariane O Menezes1, Carla B Andreucci2, Roxana Knobel3, Liduína A R Sousa4, Leila Katz5, Eduardo B Fonseca6, Claudia G Magalhães1, Wanderson K Oliveira7, Jorge Rezende-Filho8, Adriana S O Melo9, Melania M R Amorim5. 1. Medical School of Botucatu, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil. 2. Department of Medicine, Universidade Federal de São Carlos (UFSCAR), São Carlos, SP, Brazil. 3. Department of Gynecology and Obstetrics, Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brazil. 4. Department of Obstetrics and Gynecologu, Universidade Federal do Ceara, Fortaleza, CE, Brazil. 5. Instituto de Medicina Integral Professor Fernando Figueira (IMIP), Recife, PE, Brazil. 6. Division of Obstetrics and Gynecology, Universidade Federal da Paraíba, João Pessoa, PB, Brazil. 7. Fundação Oswaldo Cruz/Centro de Integração de Dados e Conhecimentos para Saúde, Salvador, BA, Brazil. 8. Faculdade de Medicina, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária da Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil. 9. Department of Obstetrics and Gynecology, Universidade Federal de Campina Grande (UFCG), Campina Grande, PB, Brazil.
Abstract
OBJECTIVE: The aim of this study was to collect and analyze data from different sources to have a general overview of COVID-19-related maternal deaths in Brazil, as well as to compare data with worldwide reports. STUDY DESIGN: We systematically searched data about COVID-19 maternal deaths from the Brazilian Ministry of Health surveillance system, State Departments of Health epidemiological reports, and media coverage. Data about timing of symptom onset and death (pregnancy or postpartum), gestational age, mode of birth, maternal age, comorbidities and/or risk factors, date of death, and place of death were retrieved when available. RESULTS: We identified 20 COVID-19-related maternal deaths, age range 20-43 years. Symptoms onset was reported as on pregnancy for 12 cases, postpartum for 3 cases, and during the cesarean section for 1 case (missing data for 4). In 16 cases, death occurred in the postpartum period. At least one comorbidity or risk factor was present in 11 cases (missing data for 4). Asthma was the most common risk factor (5/11). Ten cases occurred in the Northeast region, and nine cases occurred in the Southeast region (5 of them in São Paulo, the first epicenter of COVID-19 in the country). CONCLUSIONS: To the best of our knowledge, this is the largest available series of maternal deaths due to COVID-19. Barriers to access healthcare, differences in pandemic containment measures in the country and high prevalence of concomitant risk factors for COVID-19 severe disease may play a role in the observed disparity compared to worldwide reports on maternal outcomes.
OBJECTIVE: The aim of this study was to collect and analyze data from different sources to have a general overview of COVID-19-related maternal deaths in Brazil, as well as to compare data with worldwide reports. STUDY DESIGN: We systematically searched data about COVID-19 maternal deaths from the Brazilian Ministry of Health surveillance system, State Departments of Health epidemiological reports, and media coverage. Data about timing of symptom onset and death (pregnancy or postpartum), gestational age, mode of birth, maternal age, comorbidities and/or risk factors, date of death, and place of death were retrieved when available. RESULTS: We identified 20 COVID-19-related maternal deaths, age range 20-43 years. Symptoms onset was reported as on pregnancy for 12 cases, postpartum for 3 cases, and during the cesarean section for 1 case (missing data for 4). In 16 cases, death occurred in the postpartum period. At least one comorbidity or risk factor was present in 11 cases (missing data for 4). Asthma was the most common risk factor (5/11). Ten cases occurred in the Northeast region, and nine cases occurred in the Southeast region (5 of them in São Paulo, the first epicenter of COVID-19 in the country). CONCLUSIONS: To the best of our knowledge, this is the largest available series of maternal deaths due to COVID-19. Barriers to access healthcare, differences in pandemic containment measures in the country and high prevalence of concomitant risk factors for COVID-19 severe disease may play a role in the observed disparity compared to worldwide reports on maternal outcomes.
Authors: José P Guida; Jose G Cecatti; Renato T Souza; Rodolfo C Pacagnella; Carolina C Ribeiro-do-Valle; Adriana G Luz; Giuliane J Lajos; Fernanda G Surita; Guilherme M Nobrega; Thayna B Griggio; Charles M Charles; Maria J Miele; Silvana B Ferreira; Ricardo P Tedesco; Karayna G Fernandes; Sérgio H A Martins-Costa; José G L Ramos; Frederico J A Peret; Francisco E Feitosa; Evelyn Traina; Edson V Cunha-Filho; Janete Vettorazzi; Samira M Haddad; Carla B Andreucci; Mário D Correa-Junior; Jussara Mayrink; Marcos A B Dias; Leandro G Oliveira; Elias F Melo-Junior; Marília G Q da Luz; Maria Laura Costa Journal: Pregnancy Hypertens Date: 2022-05-10 Impact factor: 2.494
Authors: Yolanda Cuñarro-López; Pilar Pintado-Recarte; Ignacio Cueto-Hernández; Concepción Hernández-Martín; María Pilar Payá-Martínez; María Del Mar Muñóz-Chápuli; Óscar Cano-Valderrama; Coral Bravo; Julia Bujan; Melchor Álvarez-Mon; Miguel A Ortega; Juan Antonio De León-Luis Journal: J Clin Med Date: 2021-01-19 Impact factor: 4.241
Authors: Thayane Santos Siqueira; José Rodrigo Santos Silva; Mariana do Rosário Souza; Débora Cristina Fontes Leite; Thomas Edwards; Paulo Ricardo Martins-Filho; Ricardo Queiroz Gurgel; Victor Santana Santos Journal: Lancet Reg Health Am Date: 2021-09-10
Authors: Mls Takemoto; M O Menezes; C B Andreucci; R Knobel; L Sousa; L Katz; E B Fonseca; M Nakamura-Pereira; C G Magalhães; Csg Diniz; Aso Melo; Mmr Amorim Journal: BJOG Date: 2020-09-14 Impact factor: 7.331