Literature DB >> 32672790

Excess Soluble fms-like Tyrosine Kinase 1 Correlates With Endothelial Dysfunction and Organ Failure in Critically Ill Coronavirus Disease 2019 Patients.

Vincent Dupont1,2, Lukshe Kanagaratnam3, Antoine Goury1, Gaël Poitevin2, Mathieu Bard1, Gauthier Julien1, Michel Bonnivard1, Vanessa Champenois1, Violaine Noel4, Bruno Mourvillier1, Philippe Nguyen2.   

Abstract

Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here, we demonstrate that sFlt-1 plasma levels correlate with respiratory symptom severity, expression of endothelial dysfunction biomarker, and incidence of organ failure in coronavirus disease 2019 patients. Clinical Trials Registration: NCT04394195.
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  COVID-19; critical care; endothelial dysfunction; sFlt-1

Mesh：

Substances：

Year:  2021        PMID： 32672790      PMCID： PMC7454379          DOI： 10.1093/cid/ciaa1007

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  13 in total

Review 1.  Viral Endothelial Dysfunction: A Unifying Mechanism for COVID-19.

Authors:  Megha Prasad; Martin Leon; Lilach O Lerman; Amir Lerman
Journal:  Mayo Clin Proc       Date:  2021-08-19       Impact factor: 7.616

2.  sFlt-1 Is an Independent Predictor of Adverse Maternal Outcomes in Women With SARS-CoV-2 Infection and Hypertensive Disorders of Pregnancy.

Authors:  Jose Antonio Hernandez-Pacheco; Johnatan Torres-Torres; Raigam Jafet Martinez-Portilla; Juan Mario Solis-Paredes; Guadalupe Estrada-Gutierrez; Paloma Mateu-Rogell; Miguel Angel Nares-Torices; Mario Enmanuel Lopez-Marenco; Keren Rachel Escobedo-Segura; Alejandro Posadas-Nava; Jose Rafael Villafan-Bernal; Lourdes Rojas-Zepeda; Norma Patricia Becerra-Navarro; Manuel Casillas-Barrera; Mauricio Pichardo-Cuevas; Cinthya Muñoz-Manrique; Ivan Alonso Cortes-Ramirez; Salvador Espino-Y-Sosa
Journal:  Front Med (Lausanne)       Date:  2022-05-09

3.  Soluble Angiotensin-Converting Enzyme 2 as a Prognostic Biomarker for Disease Progression in Patients Infected with SARS-CoV-2.

Authors:  Noelia Díaz-Troyano; Pablo Gabriel-Medina; Stephen Weber; Martin Klammer; Raquel Barquín-DelPino; Laura Castillo-Ribelles; Angels Esteban; Manuel Hernández-González; Roser Ferrer-Costa; Tomas Pumarola; Francisco Rodríguez-Frías
Journal:  Diagnostics (Basel)       Date:  2022-04-01

4.  Plasma Total Antioxidant Capacity and Carbonylated Proteins Are Increased in Pregnant Women with Severe COVID-19.

Authors:  Juan Mario Solis-Paredes; Araceli Montoya-Estrada; Adriana Cruz-Rico; Enrique Reyes-Muñoz; Javier Perez-Duran; Salvador Espino Y Sosa; Victor Ranferi Garcia-Salgado; Rosalba Sevilla-Montoya; Raigam Jafet Martinez-Portilla; Guadalupe Estrada-Gutierrez; Juan Alexander Gomez-Ruiz; Paloma Mateu-Rogell; Jose Rafael Villafan-Bernal; Lourdes Rojas-Zepeda; Maria Del Carmen Perez-Garcia; Johnatan Torres-Torres
Journal:  Viruses       Date:  2022-03-30       Impact factor: 5.818

5.  Multi-omics data integration and network-based analysis drives a multiplex drug repurposing approach to a shortlist of candidate drugs against COVID-19.

Authors:  Marios Tomazou; Marilena M Bourdakou; George Minadakis; Margarita Zachariou; Anastasis Oulas; Evangelos Karatzas; Eleni M Loizidou; Andrea C Kakouri; Christiana C Christodoulou; Kyriaki Savva; Maria Zanti; Anna Onisiforou; Sotiroula Afxenti; Jan Richter; Christina G Christodoulou; Theodoros Kyprianou; George Kolios; Nikolas Dietis; George M Spyrou
Journal:  Brief Bioinform       Date:  2021-11-05       Impact factor: 11.622

Review 6.  Coronavirus disease-19: The multi-level, multi-faceted vasculopathy.

Authors:  Thiago Quinaglia; Mahsima Shabani; Ikaro Breder; Harry A Silber; João A C Lima; Andrei C Sposito
Journal:  Atherosclerosis       Date:  2021-02-15       Impact factor: 6.847

7.  Increased levels of soluble fms-like tyrosine kinase-1 are associated with adverse outcome in pregnant women with COVID-19.

Authors:  J Torres-Torres; S Espino-Y-Sosa; L C Poon; J M Solis-Paredes; G Estrada-Gutierrez; A Espejel-Nuñez; A Juarez-Reyes; A Etchegaray-Solana; Y Alfonso-Guillen; L Aguilar-Andrade; J A Hernández-Pacheco; J R Villafan-Bernal; R J Martinez-Portilla
Journal:  Ultrasound Obstet Gynecol       Date:  2021-12-29       Impact factor: 8.678

Review 8.  Mechanistic Insights Into the Immune Pathophysiology of COVID-19; An In-Depth Review.

Authors:  Areez Shafqat; Shameel Shafqat; Sulaiman Al Salameh; Junaid Kashir; Khaled Alkattan; Ahmed Yaqinuddin
Journal:  Front Immunol       Date:  2022-03-24       Impact factor: 7.561

Review 9.  Immune responses during COVID-19 infection.

Authors:  Cléa Melenotte; Aymeric Silvin; Anne-Gaëlle Goubet; Imran Lahmar; Agathe Dubuisson; Alimuddin Zumla; Didier Raoult; Mansouria Merad; Bertrand Gachot; Clémence Hénon; Eric Solary; Michaela Fontenay; Fabrice André; Markus Maeurer; Giuseppe Ippolito; Mauro Piacentini; Fu-Sheng Wang; Florent Ginhoux; Aurélien Marabelle; Guido Kroemer; Lisa Derosa; Laurence Zitvogel
Journal:  Oncoimmunology       Date:  2020-08-25       Impact factor: 8.110

Review 10.  COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects.

Authors:  David M Smadja; Steven J Mentzer; Michaela Fontenay; Mike A Laffan; Maximilian Ackermann; Julie Helms; Danny Jonigk; Richard Chocron; Gerald B Pier; Nicolas Gendron; Stephanie Pons; Jean-Luc Diehl; Coert Margadant; Coralie Guerin; Elisabeth J M Huijbers; Aurélien Philippe; Nicolas Chapuis; Patrycja Nowak-Sliwinska; Christian Karagiannidis; Olivier Sanchez; Philipp Kümpers; David Skurnik; Anna M Randi; Arjan W Griffioen
Journal:  Angiogenesis       Date:  2021-06-28       Impact factor: 9.596
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