| Literature DB >> 32671696 |
Qian Li1, Yang-Hong Xiang1, Xiao-Jun Liang1, Yun Zhang1, Peng-Peng Zhao1, Min Wang1, Xiao-Min Bao1, Xian-Bai Zhu1, An-Chun Deng2.
Abstract
G9a is essential for dendritic plasticity and is associated with neurological disorders. The possible relationship between age-related hearing loss and G9a expression in the auditory cortex has not been fully explored. This study aimed to understand the expression patterns of G9a-mediated histone methylations in the auditory cortex during aging. Using immunofluorescence and western blotting, we demonstrated that a significant reduction in G9a expression observed in the auditory cortex of 24-month-old rats compared to 3-month-old rats, was associated with remarkable hearing threshold elevation and hair cell loss. Correspondingly, histone H3 lysine 9 (H3K9) mono- and dimethylation (marked by H3K9me1 and H3K9me2, respectively), which were regulated by G9a activity, also evidently decreased during aging. These findings, which merit further investigation, suggest a possible association between G9a-mediated histone methylations and central age-related hearing disorders.Entities:
Keywords: Aging; Auditory cortex; G9a; Hearing loss; Histone methylations
Year: 2020 PMID： 32671696 DOI： 10.1007/s12031-020-01663-z
Source DB: PubMed Journal: J Mol Neurosci ISSN： 0895-8696 Impact factor: 3.444