Literature DB >> 32671630

Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases.

Guan Yang1,2, Yaoyao Xia1, Wenkai Ren3.   

Abstract

Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate. Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17 Treg cell-associated diseases are provided afterward. This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17 Treg cell differentiation.

Entities:  

Keywords:  Th17 cells; Treg cells; UDP-GlcNAc; glutamine; mTOR

Mesh：

Substances：

Year:  2020        PMID： 32671630     DOI： 10.1007/s11427-020-1703-2

Source DB:  PubMed          Journal:  Sci China Life Sci        ISSN： 1674-7305            Impact factor:   6.038


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