Malik Tariq Rasool1, Ashfaq Hafiz2, Saquib Zaffar Banday3, Ishtiyaq Ahmad Dar2, Shareefa Akhter4, Mohd Zubair Qureshi5, Sajad Geelani6, Nazir Ahmad Dar7. 1. Department of Radiation Oncology, State Cancer Institute, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. drmaliktariq@gmail.com. 2. Department of Radiation Oncology, State Cancer Institute, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. 3. Department of Medical Oncology, State Cancer Institute, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. 4. Department of Hematopathology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. 5. Department of Transfusion Medicine, Government Medical College, Srinagar, India. 6. Clinical Hematology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. 7. Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India.
Abstract
BACKGROUND: ABO blood group has been linked with a number of diseases including cancer. Association of ABO blood type with esophageal squamous cell carcinoma (ESCC) has been sparsely reported and the results are inconsistent. We undertook this study to analyze if any association exists between the ABO and Rh blood groups and ESCC risk. METHODS: We conducted a hospital-based case control study to analyze ABO and Rh blood groups in patients with histologically proven diagnosis of ESCC and compared them with healthy donors from the same population. ABO and Rh blood group status of general population was obtained from the blood bank at Sher-i-Kashmir Institute of Medical Sciences (SKIMS) and from original articles published from time to time. Chi-Square test was performed to look for statistical significance. RESULTS: For this study, 206 patients were prospectively enrolled. Seventy-four (35.9%) patients had blood group O. Blood groups type A and type B was found each in 59 (28.6%) patients. In 108,014 healthy donors, 35.3% had blood type O followed by type B (33.66%). There was no significant difference in any of the blood types between patients with ESCC and donors (P = 0.31). CONCLUSION: No association exists between ABO blood type and the risk of ESCC.
BACKGROUND:ABO blood group has been linked with a number of diseases including cancer. Association of ABO blood type with esophageal squamous cell carcinoma (ESCC) has been sparsely reported and the results are inconsistent. We undertook this study to analyze if any association exists between the ABO and Rh blood groups and ESCC risk. METHODS: We conducted a hospital-based case control study to analyze ABO and Rh blood groups in patients with histologically proven diagnosis of ESCC and compared them with healthy donors from the same population. ABO and Rh blood group status of general population was obtained from the blood bank at Sher-i-Kashmir Institute of Medical Sciences (SKIMS) and from original articles published from time to time. Chi-Square test was performed to look for statistical significance. RESULTS: For this study, 206 patients were prospectively enrolled. Seventy-four (35.9%) patients had blood group O. Blood groups type A and type B was found each in 59 (28.6%) patients. In 108,014 healthy donors, 35.3% had blood type O followed by type B (33.66%). There was no significant difference in any of the blood types between patients with ESCC and donors (P = 0.31). CONCLUSION: No association exists between ABO blood type and the risk of ESCC.
Entities:
Keywords:
ABO blood group; Cancer risk; Esophageal squamous cell carcinoma
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