D Tiberi1, P Vavassis1, D Nguyen1, M C Guilbert2, A Simon-Cloutier3, P Dubé3, M K Gervais3, L Sideris3, G Leblanc3, T Hijal4, M P Dufresne5, M Yassa1. 1. Department of Radiation Oncology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, QC. 2. Department of Pathology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, QC. 3. Department of Surgery, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, QC. 4. Department of Radiation Oncology, McGill University Health Centre, McGill University, Montreal, QC. 5. Department of Radiology, Hôpital Maisonneuve-Rosemont, University of Montreal, Montreal, QC.
Abstract
Introduction: Standard treatment for early-stage invasive breast cancer (bca) consists of breast-conserving surgery and several weeks of adjuvant radiotherapy (rt). Neoadjuvant single-fraction rt is a novel approach for early-stage bca. We sought to investigate the effect of delaying surgery after neoadjuvant rt with respect to the rate of pathologic response (pr). Methods: Women 65 years of age or older with a new diagnosis of stage i luminal A bca were eligible for inclusion. A single 20 Gy dose to the primary breast tumour was given, followed by breast-conserving surgery 3 months later. The primary endpoint was the pr rate assessed by microscopic evaluation using the Miller-Payne system. Results: To date, 10 patients have been successfully treated. Median age of the patients was 72 years (range: 65-84 years). In 8 patients, neoadjuvant rt resulted in a tumour pr with median residual cellularity of 3%. No immediate rt complications other than mild dermatitis were noted. Conclusions: This study demonstrates a method for delivering single-fraction rt that can lead to a high level of pr in most patients. Continued accrual to this study and subsequent trials are needed to determine the feasibility, safety, and role of this novel technique in the management of early-stage bca. 2020 Multimed Inc.
Introduction: Standard treatment for early-stage invasive breast cancer (bca) consists of breast-conserving surgery and several weeks of adjuvant radiotherapy (rt). Neoadjuvant single-fraction rt is a novel approach for early-stage bca. We sought to investigate the effect of delaying surgery after neoadjuvant rt with respect to the rate of pathologic response (pr). Methods:Women 65 years of age or older with a new diagnosis of stage i luminal A bca were eligible for inclusion. A single 20 Gy dose to the primary breast tumour was given, followed by breast-conserving surgery 3 months later. The primary endpoint was the pr rate assessed by microscopic evaluation using the Miller-Payne system. Results: To date, 10 patients have been successfully treated. Median age of the patients was 72 years (range: 65-84 years). In 8 patients, neoadjuvant rt resulted in a tumour pr with median residual cellularity of 3%. No immediate rt complications other than mild dermatitis were noted. Conclusions: This study demonstrates a method for delivering single-fraction rt that can lead to a high level of pr in most patients. Continued accrual to this study and subsequent trials are needed to determine the feasibility, safety, and role of this novel technique in the management of early-stage bca. 2020 Multimed Inc.
Entities:
Keywords:
Breast cancer; ablative radiotherapy; preoperative radiotherapy; radiosurgery; sabr; sbrt
Authors: Manisha Palta; Sua Yoo; Justus D Adamson; Leonard R Prosnitz; Janet K Horton Journal: Int J Radiat Oncol Biol Phys Date: 2010-11-17 Impact factor: 7.038
Authors: Andrea Bezjak; Rebecca Paulus; Laurie E Gaspar; Robert D Timmerman; William L Straube; William F Ryan; Yolanda I Garces; Anthony T Pu; Anurag K Singh; Gregory M Videtic; Ronald C McGarry; Puneeth Iyengar; Jason R Pantarotto; James J Urbanic; Alexander Y Sun; Megan E Daly; Inga S Grills; Paul Sperduto; Daniel P Normolle; Jeffrey D Bradley; Hak Choy Journal: J Clin Oncol Date: 2019-04-03 Impact factor: 44.544
Authors: Elizabeth Nichols; Susan B Kesmodel; Emily Bellavance; Cynthia Drogula; Katherine Tkaczuk; Randi J Cohen; Wendla Citron; Michelle Morgan; Paul Staats; Steven Feigenberg; William F Regine Journal: Int J Radiat Oncol Biol Phys Date: 2016-11-27 Impact factor: 7.038
Authors: Femke van der Leij; Sophie C J Bosma; Marc J van de Vijver; Jelle Wesseling; Sandra Vreeswijk; Sofia Rivera; Celine Bourgier; Jean-Rémi Garbay; Theodoros Foukakis; Tobias Lekberg; Desiree H J G D van den Bongard; Corine van Vliet-Vroegindeweij; Harry Bartelink; Emiel J Rutgers; Paula H M Elkhuizen Journal: Radiother Oncol Date: 2015-02-17 Impact factor: 6.280
Authors: Timothy Whelan; Robert MacKenzie; Jim Julian; Mark Levine; Wendy Shelley; Laval Grimard; Barbara Lada; Himu Lukka; Francisco Perera; Anthony Fyles; Ethan Laukkanen; Sunil Gulavita; Veronique Benk; Barbara Szechtman Journal: J Natl Cancer Inst Date: 2002-08-07 Impact factor: 13.506
Authors: Keith N Ogston; Iain D Miller; Simon Payne; Andrew W Hutcheon; Tarun K Sarkar; Ian Smith; A Schofield; Steven D Heys Journal: Breast Date: 2003-10 Impact factor: 4.380
Authors: E A Eisenhauer; P Therasse; J Bogaerts; L H Schwartz; D Sargent; R Ford; J Dancey; S Arbuck; S Gwyther; M Mooney; L Rubinstein; L Shankar; L Dodd; R Kaplan; D Lacombe; J Verweij Journal: Eur J Cancer Date: 2009-01 Impact factor: 9.162
Authors: U Veronesi; A Luini; M Del Vecchio; M Greco; V Galimberti; M Merson; F Rilke; V Sacchini; R Saccozzi; T Savio Journal: N Engl J Med Date: 1993-06-03 Impact factor: 91.245
Authors: Bernard Fisher; Stewart Anderson; John Bryant; Richard G Margolese; Melvin Deutsch; Edwin R Fisher; Jong-Hyeon Jeong; Norman Wolmark Journal: N Engl J Med Date: 2002-10-17 Impact factor: 91.245
Authors: S M Bentzen; R K Agrawal; E G A Aird; J M Barrett; P J Barrett-Lee; S M Bentzen; J M Bliss; J Brown; J A Dewar; H J Dobbs; J S Haviland; P J Hoskin; P Hopwood; P A Lawton; B J Magee; J Mills; D A L Morgan; J R Owen; S Simmons; G Sumo; M A Sydenham; K Venables; J R Yarnold Journal: Lancet Date: 2008-03-19 Impact factor: 79.321
Authors: Rupesh Kotecha; Raees Tonse; Miguel A Ramirez Menendez; Andre Williams; Zuanel Diaz; Martin C Tom; Matthew D Hall; Minesh P Mehta; Reinier Alvarez; Vitaly Siomin; Yazmin Odia; Manmeet S Ahluwalia; Michael W McDermott Journal: Sci Rep Date: 2022-03-16 Impact factor: 4.379