Literature DB >> 32669511

Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979.

Amila Pramisandi1,2, Kazuyuki Dobashi3, Mihoko Mori1,3, Kenichi Nonaka1,3, Atsuko Matsumoto1,3, Toshiyuki Tokiwa3, Mayuka Higo3, Eri Amalia4, Arif Nurkanto4,5, Daniel Ken Inaoka4,6,7, Danang Waluyo2, Kiyoshi Kita4,6,7, Tomoyoshi Nozaki4, Satoshi Ōmura3, Kazuro Shiomi1,3.   

Abstract

An Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979 was cultured to find novel scaffolds of Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitors. We obtained altenusin (1), which inhibits PfDHODH, with an IC50 value of 5.9 μM, along with other metabolites: mitorubrinol (2) and mitorubrinic acid (3). Compounds 1 and 2 inhibited PfDHODH but displayed no activity against the human orthologue. They also inhibited P. falciparum 3D7 cell growth in vitro. Compound 3 showed little PfDHODH inhibitory activity or cell growth inhibitory activity.

Entities:  

Keywords:  Plasmodium falciparum; Talaromyces pinophilus; dihydroorotate dehydrogenase; malaria

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Substances：

Year:  2020        PMID： 32669511     DOI： 10.2323/jgam.2019.11.007

Source DB:  PubMed          Journal:  J Gen Appl Microbiol        ISSN： 0022-1260            Impact factor:   1.452


  2 in total

1.  Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target.

Authors:  Dan Sato; Endah Dwi Hartuti; Daniel Ken Inaoka; Takaya Sakura; Eri Amalia; Madoka Nagahama; Yukina Yoshioka; Naotoshi Tsuji; Tomoyoshi Nozaki; Kiyoshi Kita; Shigeharu Harada; Makoto Matsubayashi; Tomoo Shiba
Journal:  Genes (Basel)       Date:  2020-12-07       Impact factor: 4.096

2.  Identification of 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine Derivatives as Novel Selective Inhibitors of Plasmodium falciparum Dihydroorotate Dehydrogenase.

Authors:  Endah Dwi Hartuti; Takaya Sakura; Mohammed S O Tagod; Eri Yoshida; Xinying Wang; Kota Mochizuki; Rajib Acharjee; Yuichi Matsuo; Fuyuki Tokumasu; Mihoko Mori; Danang Waluyo; Kazuro Shiomi; Tomoyoshi Nozaki; Shinjiro Hamano; Tomoo Shiba; Kiyoshi Kita; Daniel Ken Inaoka
Journal:  Int J Mol Sci       Date:  2021-07-05       Impact factor: 5.923
  2 in total

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