| Literature DB >> 32668229 |
Lieselotte Vande Walle1, Mohamed Lamkanfi2.
Abstract
Proteolytic maturation of the pore-forming protein gasdermin D (GSDMD) by inflammasome-activated caspase-1 is crucial for initiating pyroptosis, a lytic form of cell death. In this issue of Immunity, Lui et al. report the X-ray structure of the caspase-1-GSDMD complex, mapping the interaction interfaces that determine recognition and cleavage of GSDMD by inflammatory caspases.Entities:
Year: 2020 PMID： 32668229 DOI： 10.1016/j.immuni.2020.06.019
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745