| Literature DB >> 32668224 |
Mohna Bandyopadhyay1, Adriana T Larregina2.
Abstract
The role of keratinocyte metabolism in psoriasis is not fully elucidated. In this issue of Immunity, Lou et al. describe that interleukin-17 (IL-17) re-programs the urea cycle in keratinocytes increasing polyamines that stabilize RNA-Ag-complexes that upon cellular turnover activate dendritic cells, which amplify psoriasis inflammation.Entities:
Year: 2020 PMID： 32668224 DOI： 10.1016/j.immuni.2020.06.015
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745