Literature DB >> 3266797

Anti-inflammatory and peripheral analgesic activity of esculetin in vivo.

A Tubaro1, P Del Negro, E Ragazzi, S Zampiron, R Della Loggia.   

Abstract

Esculetin determined a reduction in oedema and granulocyte infiltration in the Croton oil ear test in vivo. The drug was able to inhibit Acethylcholine-writhing test and showed a LD50 of 1450 mg/kg i.p. and greater than 2000 mg/kg by mouth. In our experimental conditions, esculetin has an anti-inflammatory and analgesic effect.

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Year:  1988        PMID： 3266797     DOI： 10.1016/s0031-6989(88)80847-6

Source DB:  PubMed          Journal:  Pharmacol Res Commun        ISSN： 0031-6989


  7 in total

1.  UDP-Glucuronosyltransferases 1A6 and 1A9 are the Major Isozymes Responsible for the 7-O-Glucuronidation of Esculetin and 4-Methylesculetin in Human Liver Microsomes.

Authors:  Lijun Zhu; Linlin Lu; Shan Zeng; Feifei Luo; Peimin Dai; Peng Wu; Ying Wang; Liang Liu; Ming Hu; Zhongqiu Liu
Journal:  Drug Metab Dispos       Date:  2015-04-08       Impact factor: 3.922

2.  Suppression of the Wnt signaling pathway may contribute to the inhibition of proliferation of human hepatocellular carcinoma SMMC-7721 cells by esculetin.

Authors:  Xinfeng Fan; Haiyuan Du; Yaogui Sun; Junbing Jiang; Zhirui Wang; Wei Yin; Kuohai Fan; Hongquan Li
Journal:  Oncol Lett       Date:  2017-06-09       Impact factor: 2.967

3.  Esculetin has therapeutic potential via the proapoptotic signaling pathway in A253 human submandibular salivary gland tumor cells.

Authors:  Su-Bin Park; Woo Kwon Jung; Hyung Rae Kim; Hwa-Young Yu; Yong Hwan Kim; Junghyun Kim
Journal:  Exp Ther Med       Date:  2022-06-22       Impact factor: 2.751

4.  Esculetin, a natural coumarin compound, evokes Ca(2+) movement and activation of Ca(2+)-associated mitochondrial apoptotic pathways that involved cell cycle arrest in ZR-75-1 human breast cancer cells.

Authors:  Hong-Tai Chang; Chiang-Ting Chou; You-Sheng Lin; Pochuen Shieh; Daih-Huang Kuo; Chung-Ren Jan; Wei-Zhe Liang
Journal:  Tumour Biol       Date:  2015-10-28

5.  Esculetin ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats.

Authors:  Yun-Chen Tien; Jung-Chun Liao; Chuan-Sung Chiu; Tai-Hung Huang; Chih-Yang Huang; Wen-Te Chang; Wen-Huang Peng
Journal:  Int J Mol Sci       Date:  2011-06-16       Impact factor: 5.923

Review 6.  Safety Profile of Nutraceuticals Rich in Coumarins: An Update.

Authors:  Simona Codruta Heghes; Oliviu Vostinaru; Cristina Mogosan; Doina Miere; Cristina Adela Iuga; Lorena Filip
Journal:  Front Pharmacol       Date:  2022-01-24       Impact factor: 5.810

7.  Esculetin and Fucoidan Attenuate Autophagy and Apoptosis Induced by Zinc Oxide Nanoparticles through Modulating Reactive Astrocyte and Proinflammatory Cytokines in the Rat Brain.

Authors:  Woo-Ju Song; Jeongtae Kim; Taekyun Shin; Myeong-Seon Jeong; Kil-Nam Kim; Jang-Hyuk Yun; Myung-Bok Wie
Journal:  Toxics       Date:  2022-04-16
  7 in total

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