Magalie Geneviève1,2, Albane Sartorius3, Magali Giral4,5, Bénédicte Janbon6, Pierre Merville7,8, Christophe Legendre9,10, Christian Combe7,8, Karine Moreau7. 1. Service de Néphrologie Dialyse, Hôpital Privé Francheville, 4 Place Francheville, 24000, Périgueux, France. magalie-genevieve@hotmail.fr. 2. Service de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France. magalie-genevieve@hotmail.fr. 3. Service de Néphrologie Dialyse Transplantation, Hôpital Foch, Suresnes, France. 4. Centre Hospitalier Universitaire de Nantes, Institut Transplantation Urologie Néphrologie, Nantes, France. 5. Université de Nantes, Nantes, France. 6. Service Néphrologie-Transplantation Rénale-Dialyse, Centre Hospitalier Universitaire de Grenoble, Grenoble, France. 7. Service de Néphrologie Transplantation Dialyse, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France. 8. Université de Bordeaux, Bordeaux, France. 9. Service de Néphrologie Dialyse Transplantation, Hôpital Necker, Paris, France. 10. Hôpital Necker, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France.
Abstract
BACKGROUND: Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage. OBJECTIVE: In the present study, we first sought to determine the 5-year kidney graft survival in patients with anorexia nervosa and then to evaluate the BMI course and medical complications. METHODS: In this multicenter, retrospective, case-control study, we analyzed the impact of anorexia nervosa on graft outcomes compared to transplant recipients with low or normal BMI. RESULTS: We enrolled 137 women in this study: 19 with anorexia nervosa, 59 with low BMI (BMI < 18.5 kg/m2), and 59 with normal BMI (18.5-24.9 kg/m2). Anorexia nervosa was significantly associated with lower graft survival compared to either of the other groups (hazard ratio 5.5 [95% CI 3.4-8.9], p = 0.005); there was no difference in graft survival between patients with low or normal BMI. Cardiovascular complications were more frequent in the anorexia nervosa group (37%) than in patients with low (6%) or normal BMI (7%) (p = 0.001). CONCLUSION: We conclude that patients with anorexia nervosa should be considered a high-risk group. LEVEL OF EVIDENCE: Level III, evidence obtained from well-designed cohort or case-control analytic studies.
BACKGROUND:Anorexia nervosa is a condition associated with poor outcomes in a variety of circumstances such as recurrence of eating disorders, psychiatric disorders, and organ damage. OBJECTIVE: In the present study, we first sought to determine the 5-year kidney graft survival in patients with anorexia nervosa and then to evaluate the BMI course and medical complications. METHODS: In this multicenter, retrospective, case-control study, we analyzed the impact of anorexia nervosa on graft outcomes compared to transplant recipients with low or normal BMI. RESULTS: We enrolled 137 women in this study: 19 with anorexia nervosa, 59 with low BMI (BMI < 18.5 kg/m2), and 59 with normal BMI (18.5-24.9 kg/m2). Anorexia nervosa was significantly associated with lower graft survival compared to either of the other groups (hazard ratio 5.5 [95% CI 3.4-8.9], p = 0.005); there was no difference in graft survival between patients with low or normal BMI. Cardiovascular complications were more frequent in the anorexia nervosa group (37%) than in patients with low (6%) or normal BMI (7%) (p = 0.001). CONCLUSION: We conclude that patients with anorexia nervosa should be considered a high-risk group. LEVEL OF EVIDENCE: Level III, evidence obtained from well-designed cohort or case-control analytic studies.
Entities:
Keywords:
Anorexia nervosa; Body mass index; Graft survival; Kidney transplantation